L. Mao

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance

This paper develops a radio-theranostic approach targeting LRRC15 to image and treat cancer, showing tumor reduction and reversal of immunotherapy resistance.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast Cancer

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

Systematic mining and functional analysis of factors regulating wheat spike development for breeding selection

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

Exploring the genome and protein space of viruses

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

Wounding promotes root regeneration through a cell wall integrity sensor, the receptor kinase FERONIA

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

Plant Virus Database: a resource for exploring the diversity of plant viruses and their interactions with hosts

The paper builds a comprehensive Plant Virus Database (PVD) containing 3,206 virus species and 9,604 host interactions, revealing significant virome differences between plant groups and regions.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

Identification of age and ethnicity specific gene expression biomarkers for immune aging

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

A Systematic and Consistent Assay for High-throughput Characterization of Stalk Quality in Sugarcane by Near-infrared Spectroscopy

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection

This study compares the early host responses to SARS-CoV-2, SARS-CoV, and MERS-CoV infections using transcriptome analysis, revealing distinct patterns of cytokine and antiviral gene expression.

Longitudinal ultrasonic dimensions and parametric solid models of the gravid uterus and cervix

This study uses ultrasound imaging and biomechanical modeling to analyze uterine and cervical dimensions during pregnancy, providing reliable measurements for future computational biomechanical studies.

Non-antibiotic pharmaceuticals can enhance the spread of antibiotic resistance via conjugation

This study shows non-antibiotic pharmaceuticals can increase antibiotic resistance spread via conjugation by enhancing ROS production and cell membrane permeability.

The Role of the Public Health Service Equalization Program in the Control of Hypertension in China: Results from a Cross-sectional Health Interview Survey

This study evaluates the impact of China's Public Health Service Equalization Program on hypertension control using survey data, finding improved control rates and regional variability linked to administrative systems.

Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

This study shows that triclosan exposure induces antibiotic resistance in E. coli through genetic mutations and gene expression changes.