A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons
Y. Chai, D. Li, W. Gong, J. Ke, D. Tian, Z. Chen, A. Guo, Z. Guo, W. Li, W. Feng, G. Ou
The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.
bioRxiv · Jul 19, 2023 · PreprintCell Biology