H. Gao

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This paper simulates Ca2+ oscillations in astrocytes under amyloid beta influence in Alzheimer's disease, showing A{beta} alters Ca2+ dynamics through multiple pathways.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This study shows a recombinant adenovirus vaccine protects rhesus macaques from SARS-CoV challenge by inducing immune responses and reducing lung damage.

The paper investigates differential gene expression and ecological interactions between denitrifying polyphosphate and glycogen accumulating organisms in wastewater treatment processes, finding elevated nitrite reductase expression and potential cooperation in reducing nitric oxide.

This study identifies genetic variants in sorghum associated with resistance to the parasitic weed Striga hermonthica, revealing balancing selection and tradeoffs in resistance mechanisms.

The paper shows mutant KRAS induces T cells to become immune-suppressive Treg-like cells through exosomes, sera, or direct transfection, with single-cell sequencing identifying the interferon pathway as the mechanism.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

This paper introduces a novel reporter gene assay for pyrogen detection using NF-κB activation in RAW 264.7 cells, showing sensitivity and applicability to various biological products.

This study identifies integrating vectors for Amycolatopsis marina using TG1 and R4 integrases, enabling site-specific genome integration in rare Actinomycetes.

This study shows that mitotic regulators and the SHP2-MAPK pathway promote insulin receptor endocytosis and feedback regulation of insulin signaling, improving insulin sensitivity when feedback is blocked.

This study identifies 535 novel genetic loci associated with blood pressure traits in over one million individuals of European ancestry.

This study identifies sexual lineage-specific DNA methylation in Arabidopsis that regulates meiosis by controlling gene expression through RNA-directed DNA methylation.