H. Jiao

Rbbp8nl contributes to resistance to anticancer immunotherapy by creating a non-inflamed tumor microenvironment and attenuating CD8+ T cell infiltration

This study identifies RBBP8NL as a factor that reduces immune response in tumors by creating a non-inflammatory microenvironment and limiting CD8+ T cell infiltration, suggesting it as a target for improving immunotherapy.

Nerve Growth Factor Receptor Limits Inflammation to Promote Remodeling and Repair of Osteoarthritic Joints

This study identifies NGFR's role in limiting inflammation to promote joint remodeling and repair in osteoarthritis by modulating NF-κB and BMP-SMAD1 signaling.

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1

This study determines cryoEM structures of ZIKV NS1 with two groups of antibodies, revealing distinct epitope recognition mechanisms and protective efficacy differences.

Autologous iPSC- and MSC-derived Chondrocyte Implants for Cartilage Repair in a Miniature Pig Model

This study compares autologous iPSC- and BMSC-derived chondrocyte implants in minipigs, finding iMSC-Ch implants produce more hyaline cartilage-like tissue.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

Engineered human mesenchymal stem cells as new vaccine platform for COVID-19

This paper describes engineered human mesenchymal stem cells as a vaccine platform for COVID-19, showing effective and fast antibody responses.