Author

K. Lan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 3 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Assay:proteomics· 6 Research Focus:drug response / drug discovery· 5 Organism:human· 4 Organism:rat· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Y. Chen· 9 shared H. Yan· 5 shared K. Xu· 5 shared Z. Zhang· 5 shared L. Zhou· 4 shared M. Guo· 4 shared X. Wang· 4 shared Y. Zhao· 4 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

9 shared papersMicrobiology

Y. Chen

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

SARS-CoV-2 S protein antagonizes type I interferon downstream signal pathway through interacting and attenuating phosphorylation of STAT1/STAT2

W. Ni, W. Li, Z. Cai, W. Guo, Y. Zheng, Y. Zhao, Z. Wu, S. Liang, J. Ye, X. Guo, D. Zhou, X. Wu, C. Zhou, M. Tang, Y. Chen, , K. Xu

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

bioRxiv · Jun 6, 2022Microbiology

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

L. Ai, Y. Li, L. Zhou, H. Zhang, W. Yao, J. Han, J. Wu, R. Wang, W. Wang, P. Xu, Z. Li, C. Wei, H. Chen, J. Liang, M. Guo, , Y. Hu

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

bioRxiv · Feb 10, 2022Immunology

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

H. Yan, X. Wang, Q. Xiong, L. Cao, C. Ma, C. Liu, J. Si, P. Liu, M. Gu, C. Wang, L. Shi, F. Tong, M. Huang, C. Zhao, J. Li, , K. Lan

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

bioRxiv · Jan 24, 2022Microbiology

Construction of a potent pan-vaccine based on the evolutionary tendency of SARS-CoV-2 spike protein.

Y. Zhao, W. Ni, S. Liang, L. Dong, M. Xiang, Z. Cai, D. Niu, Q. Zhang, D. Wang, Y. Zheng, Z. Zhang, D. Zhou, W. Guo, Y. Pan, X. Wu, , K. Lan

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

bioRxiv · Dec 21, 2021 · PreprintMicrobiology

A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques

J. Yu, W. Yao, Y. Hu, S. Wu, J. Li, H. Zhou, K. Hong, J. Chen, L. Liu, K. Lan, F.-C. Zhu, Y. Liu

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

bioRxiv · Nov 3, 2021 · PreprintImmunology

Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library

Q. Liu, C. Cai, Y. Huang, L. Zhou, Y. Guan, S. Fu, Y. Lin, T. Yang, X. Liang, N. Wang, F. Zhang, Q. Sun, Y. Bai, Y. Chen, H. Yan, , Y. Xiong

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

bioRxiv · Aug 7, 2021 · PreprintMicrobiology

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

H. Wang, L. Zhang, C. Zeng, J. Feng, D. Wang, M. He, A. Jiang, Y. Cao, X. Guo, J. Liu, K. Yan, H. Tang, K. Xu, C. Fan, D. Guo, , Y. Chen

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

bioRxiv · Jul 9, 2021 · PreprintImmunology

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

L. Bai, Y. Zhao, J. Dong, S. Liang, M. Guo, X. Liu, X. Wang, Z. Huang, X. Sun, Z. Zhang, L. Dong, Q. Liu, Y. Zheng, D. Niu, M. Xiang, , K. Xu

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

bioRxiv · Oct 14, 2020Microbiology

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage

H. Yan, H. Jiao, Q. Liu, Z. Zhang, X. Wang, M. Guo, B.-J. Wang, K. Lan, Y. Chen, H. Zhao

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

bioRxiv · Sep 8, 2020Ecology

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

R. Xiong, L. Zhang, S. Li, Y. Sun, M. Ding, Y. Wang, Y. Zhao, Y. Wu, W. Shang, X. Jiang, J. Shan, Z. Shen, Y. Tong, L. Xu, Y. Chen, , K. Xu

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Protein & Cell · Aug 4, 2020Peer-reviewedMicrobiology

Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals during COVID-19 Outbreak

Y. Liu, Z. Ning, Y. Chen, M. Guo, Y. Liu, N. K. Gali, L. Sun, Y. Duan, J. Cai, D. Westerdahl, X. Liu, K.-f. Ho, H. Kan, Q. Fu, K. Lan

The paper measures SARS-CoV-2 RNA concentration in aerosols from different areas of Wuhan hospitals during the COVID-19 outbreak and finds that aerosol transmission is possible under certain conditions.

bioRxiv · Mar 8, 2020 · PreprintMicrobiology