B. Lv

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Regulation of Hedgehog Signaling Through Arih2-Mediated Smoothened Ubiquitination and Endoplasmic Reticulum-Associated Degradation

This study identifies Arih2-mediated Smo ubiquitination and ERAD as critical regulators of Hedgehog signaling, showing that Arih2{beta} prevents mislocalized Smo from disrupting pathway activity.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

Ubiquitin Links Smoothened to Intraflagellar Transport to Regulate Hedgehog Signaling

The paper shows that ubiquitination regulates Smo's ciliary levels by linking it to intraflagellar transport, controlling Hedgehog signaling.

Single-Cell RNA Sequencing Reveals Regulatory Mechanism for Trophoblast Cell-Fate Divergence in Human Peri-Implantation Embryo

The paper uses single-cell RNA sequencing to identify TBX3 as a key regulator of trophoblast differentiation during human peri-implantation development.

The rice G protein γ subunit qPE9-1 positively regulates grain-filling process by interacting with abscisic acid and auxin

This study shows that qPE9-1, a rice Gγ subunit, enhances grain-filling by increasing starch accumulation and gene expression related to sucrose metabolism and starch biosynthesis through interactions with ABA and IAA.