M. Zhang

This paper corrects spatially-variant optical aberrations in 3D single-molecule localization microscopy using a computational phase retrieval method with a vectorial PSF model.

This paper introduces TetTCR-Seq to link TCR sequences to their antigens in single cells and identifies neo-antigen-specific TCRs with no cross-reactivity.

This paper introduces Hessian-SMLM, a method to reduce pixel-dependent readout noise in sCMOS cameras for single-molecule localization microscopy, improving imaging time resolution.

This paper shows that transmural mean hoop stress of the aortic wall can be calculated from in vivo images using thin-walled models without needing patient-specific material properties or residual deformations.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

The paper uses single-molecule tracking to show SctQ and SctL form stable cytosolic complexes, revealing dynamic regulatory mechanisms in type 3 secretion.

This paper investigates the membrane topology of GP3 in PRRSV, showing it has an unusual hairpin-like structure that explains its partial secretion from cells.

The paper models the fusion initiation state structures of Ebola GP and Zika E proteins using computational approaches, enhancing understanding of neutralizing antibodies.

The paper investigates SAM-SAM domain interactions in Eph receptors and identifies SAMD5 as a new binding partner, explaining disease-related mutations.

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.

The paper identifies a pathway where FIP200 and CTAGE5 remodel ER-exit sites to generate COPII vesicles that contribute to autophagosome biogenesis during starvation.

The paper presents the first structure of PSII from Thermosynechococcus elongatus without the Mn4CaO5-cluster, revealing a pre-organized ligand shell for its assembly.