P. Kumar

This paper investigates the conformational dynamics of SARS-CoV-2 NSP6 protein, focusing on regions 91-112 and 231-290 outside the membrane, using molecular dynamics simulations and reductionist approaches.

This study identifies Snail's role in maintaining stem/progenitor state in skin epithelial cells and carcinomas via Mindin-mediated autocrine signaling.

This study shows that the IL-33-ILC2 pathway protects against amebic colitis by reducing inflammation and promoting tissue repair in mice.

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.

This paper introduces a sustainable method using tetrabutylammonium hydroxide to extract and purify microbial melanin from Streptomyces hyderabadensis, achieving higher yields and recyclability compared to conventional methods.

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

This paper investigates how environmental factors affect the conformation of the C-terminal domain of the SARS-CoV-2 envelope protein, showing it transitions between disordered, membrane-bound, and amyloid states.

This study identifies immunodominant T-cell epitopes in SARS-CoV-2 spike antigen and shows pre-existing T-cell immunity in unexposed individuals, suggesting prior exposure to common viruses like Influenza and CMV.

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

This study uses in vivo imaging to show that Siglec-1/CD169 on sentinel macrophages facilitates retrovirus transmission through multiple routes.

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

This paper introduces parallel-iLIFE, a high-throughput volume flow cytometry method that enables real-time analysis of mitochondrial networks in HeLa cells with sub-cellular resolution.

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.

This study investigates the conformational dynamics of SARS-CoV-2 NSP1 C-terminal region in isolation and under different solvent environments, finding it intrinsically disordered with conformational changes induced by SDS, TFE, and DOPC.

This study investigates resveratrol's binding to an oncogene promoter DNA sequence using spectroscopic and molecular dynamics methods, revealing it binds to the minor groove near AT basepairs.

The paper shows that CDT is recognized by the TLR2/6 heterodimer, leading to NF-κB and MAPK pathway activation in mice during CDI.

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

This paper infers the migration of the Todas to high elevations in the Western Ghats around 3500 cal. yr BP using palaeofire and lipid biomarker records.

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

This study isolates and characterizes bacterial endophytes from Salicornia brachiata, identifying bioactive compounds with antimicrobial potential.

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

The paper identifies DTD2, an archaeal-derived gene, as critical for plant adaptation to land by detoxifying acetaldehyde through NEDAT deacylation.

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

The paper defines totipotency using increasing stringency criteria and evaluates candidate cell types in mice, finding that expanded pluripotent states do not show higher totipotency than conventional embryonic stem cells under in vivo conditions.

The paper examines the evolution of chemical defenses in Erysimum plants, finding that ancestral and novel defenses evolved independently without trade-offs.

This study uses bioluminescent imaging to monitor HIV-1 infection dynamics in humanized mice during and after antiretroviral therapy, showing rebound in previously infected lymphoid tissues.