P. Kumar

This study identifies how melanoma cells use pericyte:endothelial cell signaling during brain invasion, showing that Sox9hi mesenchymal cells use Snail1-dependent mechanisms while Sox10hi cells form clusters.

The paper updates the M. tuberculosis H37Rv reference genome using Bact-Builder, revealing 6.4 kb of new sequence and ten new regions in widely used strains.

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

The paper designs cell-permeable multifunctional ligands for HaloTag fusions that enable protein labeling and translocation, using Si-rhodamines with low KL-Z and high logD7.4 values.

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

The paper introduces a high-throughput imaging cytometry system (SMMIC) that enables volumetric interrogation of live specimens with high resolution and flow rate.

The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.

The paper identifies herbacetin and caffeic acid phenethyl ester as inhibitors of dengue and chikungunya virus MTases, revealing their mechanism of action and antiviral efficacy.

This study identifies LKB1 as essential for carotid body chemosensing and the hypoxic ventilatory response, showing divergence in LKB1 and AMPK dependency between the carotid body and the HVR.

This study shows Mindin regulates distinct fibroblast subpopulations through different Src family kinases during fibrosis and cancer.

The paper identifies an allosteric site in a L,D-transpeptidase that binds the sugar moiety of PG substrates and a second β-lactam molecule, revealing cooperative binding with the catalytic site.

This study uses molecular dynamics simulations and experimental validation to show that the ZIKV NS1 beta-roll domain is intrinsically disordered and the beta-ladder domain is highly flexible.

This study uses cryo-electron tomography to reveal the architecture of CHIKV spherules and presents a mathematical model explaining their membrane remodeling.

This study shows that Salmonella Typhimurium modulates SUMOylation by regulating AP-1 transcription factors, affecting inflammatory responses and infection outcomes.

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

This study shows that dual inhibition of cathepsin-L and 3CL-Pro by GC-376 effectively inhibits SARS-CoV-2 infection, including the Omicron variant, in highly susceptible cell lines.

This study identifies Mindin as a key driver of fibrosis in a new mouse model of systemic sclerosis, showing its role in inducing inflammation and collagen production in fibroblasts.

The paper investigates the binding of the FDA-approved drug Mitoxantrone dihydrochloride to the C-terminal region of SARS-CoV-2 NSP1 and suggests potential therapeutic implications.

This study characterizes the structure, dynamics, and inhibition of Staphylococcus aureus TrmK, identifying a cryptic binding pocket for drug discovery.

This study investigates the conformational dynamics of Zika virus NS4B protein using molecular dynamics simulations and experiments, identifying the cytosolic region as intrinsically disordered and showing its dynamic behavior under different conditions.

The paper investigates how deletions in SARS-CoV-2 Nsp1 affect protein stability and translation inhibition, finding that certain deletions reduce translation inhibition while others impact interferon response.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This study investigates cardenolide transport patterns in Erysimum cheiranthoides, finding maternal control of seed cardenolides and root cardenolide profiles determined by aboveground genotype.

The paper solves the native structure of a human GBP coatomer that coats cytosolic bacteria and functions as an antimicrobial signaling platform.

The paper identifies a hierarchical GBP network that regulates cytosolic LPS recognition and sepsis by coordinating caspase-11 and gasdermin D functions.

This study identifies that BRCA1 promoter methylation (BRCA1meth) leads to adaptive recovery of BRCA1 expression and poorer response to platinum chemotherapy compared to BRCA mutations, while immune signals enhance response in BRCA-proficient cancers.

This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.