L. Xiang

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

This study demonstrates that peptide amphiphile nanostructures enhance cancer imaging and therapy by hitchhiking on endogenous biomolecules to target tumors effectively.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

Single-molecule displacement mapping indicates unhindered intracellular diffusion of small (<~1 kDa) solutes

The paper uses single-molecule displacement mapping to show small solutes diffuse freely in cells, with high diffusivity regions and localized slowdowns.

Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion

The paper uses single-molecule displacement mapping to show that positive charges impede protein diffusion in organelles, while negative charges do not, with an exception in the ER protein PPIB.

Enrichment of breast cancer stem cells following cytotoxic chemotherapy is mediated by hypoxia-inducible factors

This study shows that cytotoxic chemotherapy in TNBC increases BCSCs via HIFs, leading to relapse, and that HIF inhibitors can block this effect.

Benzopyrene biodegradation by multiple and individual mesophilic bacteria in axenic conditions and in soil samples

The paper isolates three bacterial strains capable of degrading benzo[a]pyrene and evaluates their individual and consortium growth and degradation rates under controlled conditions.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Excitation spectral microscopy for highly multiplexed fluorescence imaging and quantitative biosensing

This paper introduces excitation spectral microscopy to enable high multiplexing of fluorescent targets in live cells with low crosstalk and high temporal resolution.

Apoptotic Extracellular Vesicles (ApoEVs) Safeguard Liver Homeostasis and Regeneration via Assembling an ApoEV-Golgi Organelle

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

Modulation of Transient receptor potential melastatin 3 by protons through its intracellular binding sites

This study identifies three intracellular residues that modulate TRPM3 channel activity through pH sensitivity, revealing their role in proton-induced inhibition and channel gating.

Robotic Assay for Drought (RoAD): An Automated Phenotyping System for Brassinosteroid and Drought Response

The paper introduces RoAD, a robotic system for automated BR and drought response experiments in Arabidopsis and maize, using imaging and machine learning to measure plant traits.

Reconstruction and dynamics of human intestinal microbiome observed in situ

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

Crif1 Promotes Osteoporosis in Mice after Radiation

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

Single-molecule displacement mapping unveils nanoscale heterogeneities and charge effects in intracellular diffusivity

This study introduces SMdM to map nanoscale diffusivity variations in the cell and finds that local diffusivity is heterogeneous and influenced by subcellular structures and molecular charge.

Automated Adherent Cell Elimination by a High-Speed Laser Mediated by a Light-Responsive Polymer

The paper develops a laser-based system for automated removal of differentiated cells from pluripotent stem cell cultures using light-responsive polymers and machine learning.