Y. Zhu

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

This paper develops an automated real-time PCR assay for rapid detection of Candida auris using the BD MAX system, achieving high sensitivity and specificity in clinical samples.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

This study shows arsenite exposure reduces p300 and H3K27ac at enhancers in MEF cells, affecting gene expression and potentially contributing to arsenic-related disease.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

The paper uses Drop-seq to profile over 4,000 single cells from Arabidopsis root tissue, identifying cell types and gene expression changes during endodermis development.

This study investigates the molecular mechanisms of ST toxin secretion and delivery in ETEC, identifying key factors like TolC and EtpA, and potential therapeutic targets.

This study identifies USP7 as a key driver of T-cell leukemia by stabilizing NOTCH1 and JMJD3, showing USP7 inhibition blocks leukemia growth and suggests it as a therapeutic target.

This study identifies posttranslational modifications of RioK1 that regulate its stability and oncogenic activity in colorectal and gastric cancers.

This study identifies three states of the ATP-gammaS-bound human proteasome, showing nucleotide-driven remodeling of the AAA-ATPase channel controls CP gate opening.

This study identifies NFATc2 as a regulator of lung tumor-initiating cells via the NFATc2/SOX2/ALDH1A1 axis, linking it to drug resistance and poor patient outcomes.