transcription & RNA processing

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

This study shows that the disordered N-terminal region of SETD2 regulates its proteasome-mediated decay, affecting H3K36me3 deposition and transcriptional fidelity.

This study reprograms human adipocytes into induced multipotent stem cells using PDGF-AB and 5-Azacytidine, showing their ability to regenerate tissues without ectopic growth.

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

This study reannotates the VZV transcriptome using RNA sequencing to identify 136 polyadenylated RNAs, including ORFs, non-canonical ORFs, ORF fusions, and ncRNAs, revealing unexpected kinetic classes of viral transcripts.

This study develops biofabricated myo-substitutes to restore skeletal muscle mass, 3D structure, and function in volumetric muscle loss models.

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

This paper develops a thrombin-free method to polymerize fibrinogen into gels, enabling controlled processing and new applications in tissue engineering.

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

This paper introduces POP-seq, a method to profile bacterial nucleoid openness, linking genome structure to transcriptional and phenotypic outcomes.

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

PerSort isolates and characterizes persister subpopulations in Mycobacterium tuberculosis, revealing their multidrug tolerance and metabolic state, and enabling their elimination under stress conditions.

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

The paper shows that exonic stem-loops upstream of introns regulate splicing by modulating splicing factor accessibility.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

The paper uses SARS-CoV-2 genome sequencing and agent-based modeling to estimate local transmission rates during the early stages of the COVID-19 outbreak in New South Wales.

This paper shows that the THO/TREX complex components TEX1 and HPR1 are required for proper transcription termination in Arabidopsis, leading to defects in mRNA processing and growth.

This study shows that SERRATE interacts with the NEXT complex to degrade primary miRNA precursors in Arabidopsis, revealing a dual role for SERRATE in miRNA biogenesis.

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

This study shows O-GlcNAc modification regulates detained intron splicing, affecting gene expression and linking nutrient conditions to transcriptional regulation.

This study identifies E proteins as suppressors of ILC2 differentiation by repressing a transcriptional network through upregulation of repressor genes.

The paper examines how photoperiod affects the transcriptional response to seawater entry in Atlantic salmon, finding that short photoperiod impairs hypo-osmoregulation and alters gill gene expression.

The paper shows Gβγ interacts with RNA polymerase II in cardiac fibroblasts, negatively regulating fibrotic gene expression, with cell-specific signaling pathways involved.

This study synthesizes and characterizes a methacrylated bone-derived hydrogel (BoneMA) for bioprinting vascularized tissues, showing its cytocompatibility and ability to form vascular networks.

This paper introduces a 3D-printed modular LEGO-like cage scaffold system for tissue engineering that allows scalable assembly and controlled therapeutic loading.

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

The paper identifies colocalization of G-quadruplex forming sequences and m6A modifications at human pre-mRNA intron splice sites, suggesting a potential role in alternative splicing.

This paper introduces an APEX2-based method to map proteins, RNA, and DNA associated with the nuclear lamina, revealing new insights into its regulatory roles and dynamic interactions.