E. Kim

The paper develops an agent-based model to study how spatial distribution of resistant cells and fibroblasts affects the success of adaptive therapy over continuous therapy in cancer treatment.

This study investigates how condensin-driven DNA loop extrusion is influenced by supercoiling using single-molecule imaging and atomic force microscopy.

The paper characterizes NmMetQ, showing it is a lipoprotein that binds methionine analogs and activates its cognate ABC transporter, challenging the conventional localization of SBPs in Gram-negative bacteria.

This study shows stress granules regulate immune responses to dsRNA by preventing excessive inflammation and viral replication.

SongExplorer uses deep learning to discover, annotate, and segment animal acoustic signals with higher accuracy than existing methods and comparable to human experts.

This study models ASF-infected wild boar deathbeds in South Korea using surveillance data to identify spatial risk factors for ASF presence and carcass reporting.

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

This study identifies human gut bacteria that produce TH17-modulating bile acid metabolites, showing reduced levels in IBD patients.

This study develops mathematical models to predict adaptive therapy benefits for metastatic melanoma, showing potential delays in progression by 6-25 months compared to continuous therapy.

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

Yeast cohesin phase separates with DNA into liquid droplets via ATP-independent DNA bridging.

This study identifies intrinsic and extrinsic factors that drive increased basal activity of pharyngeal satellite cells compared to limb muscle satellite cells.

The paper identifies monomeric and multimeric PSII-LHCII supercomplexes in spinach leaves and shows multimeric forms have higher light-harvesting but lower thermal dissipation capabilities under low-light conditions.

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

This study shows that the MyD88-Syk axis drives inflammatory responses in macrophages by promoting ROS/RNS generation and phagocytic activity through Src, F-actin, and Rac1.

This study identifies METTL18 as an actin histidine methyltransferase that enhances breast cancer metastasis by promoting actin polymerization and Src activation.

This study shows yeast condensin complexes can traverse each other to form Z-loops, enabling dynamic DNA packaging and compaction through various looping structures.

This study presents a mechanistic epidermal model showing homeostasis leads to log-linear subclone size distributions in skin cells, with larger subclones being older due to persistence of driver mutations.

This study identifies a specific RSV genomic sequence that regulates the generation of copy-back defective viral genomes, showing that cbDVG formation is not random and can be manipulated.

This study shows that Ly6G ligation selectively inhibits β2 integrin-dependent neutrophil migration in specific inflammatory contexts.

The paper identifies the common ancestry of TALE homeobox transcription factors across Metazoa and Archaeplastida, showing their role in haploid-to-diploid transitions through heterodimerization.

This study establishes Galleria mellonella as a model to study P. destructans virulence and screens chemicals to inhibit its growth.

The paper develops a method to identify new cancer genes by integrating protein network analysis with in vivo tumorigenesis assays, finding 62 new candidates and validating two in patient data.