H. Lin

The paper introduces a novel DNA crosslinker, AP3B, which is significantly more effective than the commercial EZ-Link Psoralen-PEG3-Biotin in labeling DNA in cells and crosslinking DNA strands in vitro.

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

This study uses bioinformatics analysis to identify hif-related genes in vhl-deficient cells under hypoxia, finding both up- and down-regulated genes.

This study develops a sphere-forming assay to isolate a malignant subpopulation from a CRC cell line and identifies DPEP1 as a prognostic biomarker.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

This study shows that sialidase activity enables Fusobacterium to exploit sialoglycans, promoting its colonization and mutualistic interactions with the vaginal microbiota, which contributes to dysbiosis.

The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.

The paper identifies TPXL3 as the primary activator of α Aurora kinases in Arabidopsis, essential for embryogenesis, while TPX2 and TPXL2 have distinct roles.

This study shows PBRM1 regulates stress response and apoptosis in epithelial cells by affecting reactive oxygen species and cell viability.

This study shows that high IQGAP3 expression in breast cancer is linked to poor prognosis and resistance to radiation therapy.

This study identifies HDAC11 as a defatty-acylase that regulates type I interferon signaling by modifying SHMT2, revealing a novel function of HDAC11 beyond its deacetylase activity.

This study identifies lysine fatty acylation as a regulatory mechanism for K-Ras4a, showing that SIRT2-mediated defatty-acylation promotes oncogenic activity by enhancing endomembrane localization and interaction with A-Raf.