H. Lin

This study identifies WAPO-A1 as the causal gene for a QTL affecting spikelet number per spike in wheat and shows that the H2 haplotype significantly increases grain yield.

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

This study identifies a novel β-arrestin-2-mediated signaling pathway that mediates aPC/PAR1's anti-apoptotic effects in endothelial cells.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This study investigates the genetic and physical interactions between SQUAMOSA and SVP MADS-box proteins in wheat spike development, showing their roles in regulating meristem transitions and floral development.

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

This paper introduces statistical measures for spatial rotations and projection directions in cryoEM, accounting for molecular symmetry, and implements them in an open-source Python package.

This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study uses genetic selections to uncover the molecular mechanism of the HitRS signal transduction system in Bacillus anthracis, identifying key residues and interactions essential for TCS function.

This paper develops a probiotic using bacteria that scavenge free radicals to mitigate coral bleaching caused by reactive oxygen species during thermal stress.

This paper introduces an ultra-compact dual-band smart NEMS magnetoelectric antenna for wireless energy harvesting and magnetic field sensing in implantable medical devices.

This study identifies novel marine bacteria capable of mercury methylation, revealing their broader habitat range and oxygen tolerance.

This study demonstrates that indocyanine green (ICG) emits strong NIR-IIb fluorescence when dissolved in protein solutions, enabling high-resolution bioimaging with improved signal-to-background ratio.

This study shows that the Slp-4 C2A domain binds PIP2 with high affinity through multivalent interactions involving both specific and nonspecific lipid contacts.

SARDU-Net is a deep learning framework for designing quantitative MRI protocols by selecting informative measurements from pilot scans, achieving high information content and reproducibility.

The paper assesses twelve NR4A ligands to determine if they directly bind and modulate Nurr1 or act through effector proteins, finding some bind directly while others do not.

The paper shows natural variation in C4 enzyme expression in Arabidopsis and demonstrates that high C4 enzyme expression is neutral in rice, supporting the role of neutral variation in C4 photosynthesis evolution.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This paper shows PIWIL1 promotes gastric cancer independently of piRNA by interacting with the NMD pathway.

The paper shows that PPD1 has a stronger effect on wheat heading time than CO1 and CO2, and that these genes can function independently in photoperiodic responses.

This study examines ACE2 receptor usage by SARS-CoV-2 across 14 mammalian species, finding broad receptor activity and implications for zoonotic transmission and animal models.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study identifies LY6E as a host protein that restricts entry of human coronaviruses, including SARS-CoV-2, through a mechanism distinct from IFITM3.