S. Hu

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.

This study shows that deleting the ycgN gene in B. licheniformis increases gamma-PGA synthesis by raising intracellular ROS levels through P5C accumulation.

This study shows HBV inhibits neutrophil extracellular traps (NETs) release by reducing reactive oxygen species (ROS) and autophagy, contributing to chronic infection.

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

This study shows myricetin reduces inflammation in LPS-induced RAW 264.7 macrophages and mouse models of acute lung injury by inhibiting NF-κB and MAPK pathways.

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.

This study shows that Helicobacter pylori uses chemotaxis to overcome host-generated reactive oxygen species, enabling colonization of stomach glands.