S. Hu

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

This study identifies distinct antibody epitope repertoires in IBD patients using PhIP-seq, revealing differentially abundant antibodies associated with disease subtypes and features.

This paper introduces 4DPhenoMVS, a low-cost 3D phenotyping pipeline for tomato plants using multiview images, showing high correlation with manual measurements and environmental impact on growth.

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

The paper develops VHH-based therapeutics displayed on probiotic E. coli Nissle 1917 to target enteric pathogens, showing they can bind and neutralize virulence factors.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

This study shows that disrupting the SP-R210L isoform in aged mice impairs respiratory function and iron sequestration in alveolar macrophages, leading to chronic dysregulation and increased interstitial lung disease risk.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

The paper uses coarse-grained MD simulations to study lipid distributions and cholesterol migration around different solutes in asymmetric bilayers, revealing varied lipid partitioning and cholesterol flipping dynamics.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

This study identifies environmental and lifestyle factors shaping the gut microbiome in a large Dutch cohort, finding that most microbiome variation is due to environment rather than genetics.

This study examines whether dung beetles reduce greenhouse gas emissions from dung by mixing and burial, finding no overall reduction in CO2e and increased N2O emissions from tunneling beetles.

This study shows that TIGIT-Fc promotes antitumour immunity by enhancing CD8+ T and NK cell effector functions and inducing Th1 development, suggesting its potential as a therapeutic strategy.

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study identifies bosutinib as a radiosensitizer for breast cancer by targeting eIF4G1, enhancing radiation efficacy and reducing drug dosage.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This paper introduces MorphEUS, a morphological profiling method that classifies drugs based on their effects on Mycobacterium tuberculosis morphology, identifying both primary and off-target pathways of action.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study develops a recombinant ACE2-Ig fusion protein that neutralizes both SARS-CoV and 2019-nCoV in vitro, showing cross-reactivity and potential for diagnostic, prophylactic, and therapeutic applications.

This study identifies Blimp-1 as a positive regulator of Th2 cell development and allergic asthma through an IL-10-STAT3-Blimp-1 circuit.

The paper shows TIGIT-Fc promotes immune tolerance at the feto-maternal interface by enhancing IL-10 production and TH2 polarization in decidual CD4+ T cells, and increasing pregnancy rates in stressed mice.