C. Lei

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Ecological dynamics of the gut microbiome in response to dietary fiber

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

Autographa californica Multiple Nucleopolyhedrovirus orf13 is Required for Efficient Nuclear Egress of Nucleocapsids

This study identifies AcMNPV orf13 as essential for efficient nuclear egress of nucleocapsids during virion budding but not for occlusion body formation.

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

TIGIT-Fc Promotes Antitumour Immunity

This study shows that TIGIT-Fc promotes antitumour immunity by enhancing CD8+ T and NK cell effector functions and inducing Th1 development, suggesting its potential as a therapeutic strategy.

Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

CAR Macrophages for SARS-CoV-2 Immunotherapy

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig

This study develops a recombinant ACE2-Ig fusion protein that neutralizes both SARS-CoV and 2019-nCoV in vitro, showing cross-reactivity and potential for diagnostic, prophylactic, and therapeutic applications.

Virtual-freezing fluorescence imaging flow cytometry

This paper introduces a virtual-freezing fluorescence imaging flow cytometry method that enhances throughput without sacrificing sensitivity and spatial resolution, enabling high-dimensional analysis and classification.

TIGIT-Fc Promote Immune Tolerance at the Feto-maternal Interface

The paper shows TIGIT-Fc promotes immune tolerance at the feto-maternal interface by enhancing IL-10 production and TH2 polarization in decidual CD4+ T cells, and increasing pregnancy rates in stressed mice.

Classification of platelet aggregates by agonist type

This paper introduces a method to classify platelet aggregates by agonist type using convolutional neural networks trained on high-throughput imaging data.

Phenological matching drives wheat pest range shift under climate change

This study shows that climate change has caused a northward shift in the range of wheat pests, leading to increased crop damage despite pesticide use.

Treatment of Murine Lupus with TIGIT-Ig

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

Targeting RyR2 with a phosphorylation site-specific nanobody Reverses Dysfunction of Failing Cardiomyocytes in Rat

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.