Author

H. Duan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Assay:proteomics· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

X. ZhangiD· 3 shared C. Ding· 2 shared D. A. Wolf· 2 shared F. Wang· 2 shared G. Tian· 2 shared X. Yang· 2 shared Y. Cheng· 2 shared Y. Xu· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCancer Biology

X. ZhangORCID

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Author profile →

9 papers

Recent·Most cited

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

H. Duan, J. Ren, S. Wei, C. Li, Z. Wang, M. Li, Z. Wei, Z. Yang, Y. Liu, Y. Xie, S. Wu, W. Hu, C. Guo, X. Zhang, L. Liang, , Y. Mou

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Genome Medicine · Nov 26, 2024Peer-reviewedCancer Biology

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

H. Duan, S. Zhang, Y. Zarai, R. Oellinger, Y. Wu, L. Sun, C. Hu, G. Tian, R. Rad, Y. Cheng, T. Tuller, D. A. Wolf

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

The EMBO Journal · May 8, 2023Peer-reviewedCell Biology

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma.

A. Prosz, H. Duan, V. Tisza, P. Sahgal, S. Topka, G. T.Klus, J. Borscok, Z. Sztupinszki, T. Hanlon, M. Diossy, L. Vizkeleti, D. R. Stormoen, I. Csabai, H. Pappot, J. Vijai, , Z. Szallasi

This paper identifies NER deficiency as a targetable vulnerability in ccRCC, showing that 10% of patients may respond to irofulven based on mutational signatures and PTGR1 expression.

bioRxiv · Feb 7, 2023Cancer Biology

Single-cell functional genomics of natural killer cell evasion in blood cancers

O. Dufva, S. Gandolfi, J. Huuhtanen, O. Dashevsky, K. Saeed, J. Klievink, P. Nygren, J. Bouhlal, J. Lahtela, A. Näätänen, B. Ghimire, T. Hannunen, P. Ellonen, H. Duan, J. Theodoropoulos, , S. Mustjoki

The paper uses single-cell and genome-scale functional genomics to study how blood cancer cells evade NK cells, identifying key genes and pathways involved in resistance and sensitivity.

bioRxiv · Aug 22, 2022 · PreprintImmunology

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

X. Chi, X. Zhang, S. Pan, Y. Yu, T. Lin, H. Duan, X. Liu, W. Chen, X. Yang, Q. Ding, J. Wang, W. Yang

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

bioRxiv · Dec 25, 2021Microbiology

Isolation and characterization of a Cyprinid herpesvirus strain YZ01 from apparently healthy goldfish after rising water temperature

F. Wang, Y. Xu, Y. Zhou, C. Ding, H. Duan

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

bioRxiv · Jul 5, 2021 · PreprintMicrobiology

Electron microscopic observation of infected CCB and whole genome analysis of Koi herpesvirus isolate GY01

H. Duan, Y. Xu, Y. Zhou, F. Wang, C. Ding, J. Cao

The paper describes electron microscopy of KHV GY01 infected cells and whole genome analysis to study its characteristics and phylogenetic relationships with other KHV strains.

bioRxiv · May 21, 2020 · PreprintMicrobiology

SARS-CoV-2 proteome microarray for mapping COVID-19 antibody interactions at amino acid resolution

H. Wang, X. Hou, X. Wu, T. Liang, X. Zhang, D. Wang, F. Teng, J. Dai, H. Duan, S. Guo, Y. Li, X. Yu

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

bioRxiv · Mar 26, 2020Biochemistry

eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health

Y. Lin, F. Li, L. Huang, H. Duan, J. Fang, L. Sun, X. Xing, G. Tian, Y. Cheng, X. Yang, D. A. Wolf

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

bioRxiv · Dec 22, 2019Cell Biology