W. Sun

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

The paper identifies a novel IKK- and proteasome-independent mechanism of RelA activation in senescent cells that drives the senescence-associated secretome through transcriptional repression of NFKBIA.

This study identifies PsaE's role in regulating psaA in Yersinia pestis, showing its temperature- and pH-dependent expression and binding sites across the genome.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.

This paper shows that transmural mean hoop stress of the aortic wall can be calculated from in vivo images using thin-walled models without needing patient-specific material properties or residual deformations.

This paper develops a machine learning approach to estimate aortic wall constitutive parameters from 3D geometries at different blood pressure levels, improving efficiency over traditional inverse methods.

This study uses deep learning to estimate collagenous tissue mechanical properties from microscopy images with high accuracy.

This study develops a multi-scale computational model to investigate how mechanical factors regulate mitotic rounding in epithelial tissues, finding that all three factors—adhesion, cortical stiffness, and pressure—must be coordinated for robust rounding.