W. Sun

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

The paper identifies a non-canonical transcriptional mechanism in T-ALL where GFI1 and IKAROS cooperate to transactivate NOTCH3, independent of LSD1 binding.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This study investigates how cardiolipin and phosphatidylglycerol lipids induce structural and dynamic changes in cytochrome c, affecting its peroxidase activity during mitochondrial apoptosis.

This study uses deep learning to predict cell sizes from laser mode imaging of single-cell lasers, demonstrating sub-wavelength accuracy in both synthetic and biological cell models.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

This paper develops an adaptive optics module for multiphoton imaging in vivo, enabling high-resolution visualization of neural structures and calcium responses in deep brain and spinal cord regions of mice.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This paper introduces a probabilistic and anisotropic failure metric to improve risk stratification for ascending thoracic aortic aneurysm by incorporating patient-specific biomechanical data and uncertainty in wall strength.

This paper develops a regional difference-based evaluation method for ecosystem service value (ESV) in Gansu Province, China, showing increased ESV from 2000 to 2015 with forest and urban ecosystems contributing most.

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

This study identifies gene mutations in SARS-CoV-2 that enhance its adaptation to humans by analyzing host-genome similarity across 2594 genomes from three continents.

This paper evaluates an inactivated Newcastle disease virus expressing the SARS-CoV-2 spike protein as a cost-effective vaccine, showing immunogenicity and protective efficacy in animal models.

This paper describes NDV vector vaccines expressing SARS-CoV-2 spike protein that protect mice from viral challenge and can be produced cost-effectively in chicken eggs.

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

The paper examines IgA abundance and nuclear antigen reactivity in intestinal and fecal samples of lupus-prone mice, finding correlations with systemic autoimmunity onset.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study identifies a novel adipocyte subtype using single-nucleus RNA-Seq that regulates thermogenesis via paracrine signaling in humans and mice.

The paper uses single-cell RNA sequencing to analyze immune cell composition in brain metastases of NSCLC patients, finding reduced T cell activity and expanded M2-polarized tumor-associated macrophages.