X. Shan

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

Mutation-induced infections of phage-plasmids

This study shows how mutation-induced infections of phage-plasmids enable continuous productive infections in marine bacteria through segregational drift and loss-of-function mutations.

Annotation-free discovery of functional groups in microbial communities

This paper introduces an unsupervised method to identify functional groups in microbial communities based on abundance patterns and environmental data, validated across soil, ocean, and gut microbiome datasets.

TME induced TRAIL secretion from engineered macrophages for anti-tumor therapy

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

Investigation of white spot syndrome virus (WSSV) infection in wild crustaceans in the Bohai Sea

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

Deconstructing the association between abiotic factors and species assemblages in the global ocean microbiome

The paper identifies a core/flexible bipartition of ocean microbial taxa that best explains abiotic variance, outperforming existing functional groupings.

Biased Signaling: Distinct Ligand-directed Plasma Membrane Signalsomes Using a Common RGS/G Protein Core

The paper identifies distinct ligand-directed plasma membrane signalsomes in Arabidopsis that drive biased signaling through compartmentation and different trafficking origins.