G. Yan

Opto-Myomatrix: μLED integrated microelectrode arrays for optogenetic activation and electrical recording in muscle tissue

This paper introduces Opto-Myomatrix, a device for optogenetic muscle activation and EMG recording, achieving high optical output and low electrode impedance.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Insecticide resistance and its intensity in urban Anopheles arabiensis in Kisumu City, Western Kenya: Implications for malaria control in urban areas

This study assesses insecticide resistance in urban Anopheles arabiensis in Kisumu City, Kenya, finding high resistance to pyrethroids and elevated detoxification enzyme levels.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Aalbo1200: global genetic differentiation and variability of the mosquito Aedes albopictus

This study generates whole genome sequencing data from Aedes albopictus populations to analyze genetic differentiation and variability across tropical and temperate regions.

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Mapping potential malaria vector larval habitats for larval source management: Introduction to multi-model ensembling approaches

This paper introduces a framework for multi-model ensemble modeling to predict malaria vector larval habitats, finding that ensembled models improve prediction accuracy by 20% compared to individual models.

Vimentin intermediate filaments provide structural stability to the mammalian Golgi apparatus

This study shows vimentin intermediate filaments support Golgi structural stability, with GORAB mediating this interaction, affecting Golgi disassembly and reassembly dynamics.

Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

De-heterogeneity of the eukaryotic viral reference database (EVRD) improves the accuracy and efficiency of viromic analysis

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

This study examines mosquito resistance to PBO-synergized pyrethroids and finds that field mosquitoes are resistant despite PBO exposure, due to elevated metabolic enzyme levels and knockdown resistance mutations.

Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya

This study examines the larval ecology and sporozoite infection rates of Anopheles funestus in highland and lowland sites in western Kenya, finding that man-made ponds are most abundant for larvae and proximity to houses is a key environmental factor.

THESEUS1 modulates cell wall stiffness and abscisic acid production in Arabidopsis thaliana

This study identifies THESEUS1 as a regulator of cell wall stiffness and abscisic acid production in Arabidopsis thaliana, linking cell wall integrity to turgor pressure and drought response.

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Insecticide resistance status of indoor and outdoor resting malaria vectors in a highland and lowland site in Western Kenya

This study compares insecticide resistance in indoor and outdoor resting malaria vectors in Western Kenya, finding higher resistance in indoor populations.

Plasmodium falciparum increases its investment in gametocytes in the wet season in asymptomatic individuals

The paper shows that Plasmodium falciparum increases gametocyte density in the wet season among asymptomatic individuals, despite lower gametocyte prevalence.

Precision combination therapies based on recurrent oncogenic co-alterations

The paper develops REFLECT, a method that maps recurrent co-alteration signatures to drug combinations using multi-omic data, validating its effectiveness across 201 cohorts and 10,392 patients.

BET inhibition induces an anti-apoptotic adaptive response and therapeutic vulnerability to MCL1 inhibitors in breast cancer

This study shows BET inhibition in breast cancer triggers an anti-apoptotic response via MCL1 upregulation, and co-targeting BET and MCL1 is synergistic and effective in basal-like breast cancers.

Behavioral response of insecticide-resistant mosquitoes against spatial repellent: a modified self-propelled particle model simulation

This study simulates mosquito behavior in response to spatial repellents and insecticide resistance using a modified self-propelled particle model, finding that resistant mosquitoes may be less affected by repellents.

Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

Resting behaviour of malaria vectors in a highland and a lowland site of western Kenya: Implication on malaria vector control measures

This study examines resting behavior, host preference, and Plasmodium falciparum infection in malaria vectors in western Kenya, finding high indoor resting rates and insecticide resistance.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.