D. Lee

This study identifies bacterial filamentation as an in vivo mechanism for cell-to-cell spreading between intestinal epithelial cells in the nematode Oscheius tipulae.

This study shows that cancer hotspot mutations in Ras activate it regardless of stability, while non-hotspot mutations can be activating or deleterious depending on stability.

The paper presents a microfluidic chip for efficient multiplexed immunoassay readout using barcoded planar microparticles, achieving good accuracy with a single pipetting step.

This study samples C. elegans across Hawaii over three years, sequenced their genomes, and found seven genetic groups and 18 regions linked to local adaptation.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

This study develops and tests mechano-active microcapsules containing osteogenic factors in a large animal model to preserve bone structure after osteochondral injury.

This study shows that rod-shaped particles create granular hydrogels with better pore structure and cell invasion compared to spherical particles.

The paper examines how ecological factors influence the evolution of olfactory receptor genes and morphology in bats, finding that increased reliance on olfaction correlates with reduced genetic diversity in these genes.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

The paper identifies a gene expression signature predicting response to immune checkpoint blockade using TCR clonotype barcoding in single-cell data from a small cohort, validated in larger studies.

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

This paper designs a radial multi-offset detection pattern for in vivo phase contrast imaging of human retinal ganglion cells, achieving improved contrast and robustness compared to previous methods.

This study identifies ESRP2 as an epigenetically repressed tumour suppressor in Wilms tumour through DNA hypermethylation, showing its ability to inhibit proliferation and suppress tumour growth.

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

This paper develops a mathematical model to study how neutrophil extracellular traps (NETs) influence lung cancer invasion and metastasis, showing that tumor-associated neutrophils enhance invasion via neutrophil elastase secretion and predicting treatment responses.

The paper shows that balancing selection maintains genetic diversity in hyper-divergent regions of C. elegans, enabling adaptation despite selfing.

The paper screens FDA-approved drugs to identify inhibitors of PTP4A3 (PRL-3), finding five specific inhibitors and two broad inhibitors that block PRL-3-induced migration without affecting cell viability.

This paper introduces DNA micro-disks with index and WORM memory features to improve DNA-based data storage reliability and accessibility.

The paper identifies Sfh5 as a novel heme-binding protein with an unusual coordination mechanism, distinct from its Sec14-like PITP family members.

This paper introduces pipelines for automating tissue preview segmentation in digital pathology scanners using brightfield and darkfield microscopy.

This paper introduces a viscous medium-based sample holder for fixed-target serial femtosecond crystallography, enabling stable crystal support for various sizes and shapes.

This paper develops a method for efficient site-directed gene insertion in primary human NK cells using CRISPaint and AAV delivery, achieving up to 89% mCherry expression.

This study introduces a novel bipedal model, SLIPCOP, which uses a translating center of pressure to simulate walking across a range of speeds with improved accuracy compared to traditional models.

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

This paper introduces a robust fabrication method for three-dimensional microfluidic chips with a high density of TSVs, enabling a 100% increase in droplet generators on a single wafer.

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.

The paper shows that copy-number variation of pheromone receptor genes in C. elegans is shaped by selection and gene flow, contributing to differences in pheromone responses across habitats.

This study identifies a recessive allele in the OsLpa1 gene that significantly reduces phytic acid content in rice seeds by altering enzyme activity.