H. Liu

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

ADS-J1 disassembles semen-derived amyloid fibrils and prevents their re-aggregation, showing potential as a microbicide and treatment for amyloid diseases.

The paper analyzes the distribution and genetic diversity of ammonia-oxidizing archaea (AOA) lineages in global oceans using metagenomics data, revealing distinct ecological patterns and environmental correlations.

This study shows CRISPR-Cas9 can confer resistance to cauliflower mosaic virus by targeting coat protein sequences, leading to non-functional viral proteins and reduced infection.

This study shows estrogen protects against intervertebral disc degeneration by upregulating ER, but miR-221 reduces this protection by targeting ER.

This paper introduces a genetic strategy for sparse protein labeling in live cells, enabling long-term single-molecule tracking and revealing new insights into molecular dynamics in vivo.

The paper reports the crystal structure of the YTH domain of Mmi1 bound to DSR-containing RNA, revealing the mechanism of specific RNA recognition and its distinct function compared to other YTH domain proteins.

This study determines the crystal structures of hnRNPA2/B1's RRM domains bound to RNA substrates, revealing sequence-specific recognition and suggesting a matchmaker mechanism, but not m6A binding.

This paper validates tofacitinib as an effective anti-myeloma therapy by reversing bone marrow microenvironment-driven growth signals in vitro and in vivo.

This study identifies microbial glycoside hydrolases that disrupt biofilms and enhance antifungal efficacy against Aspergillus fumigatus and Pseudomonas aeruginosa.

This study demonstrates that Cpf1 nucleases from Francisella novicida and Lachnospiraceae bacterium ND2006 can efficiently insert genes into the rice genome via homology directed repair.

The paper introduces a method combining CRISPR imaging and sequential DNA FISH to multiplex live genomic locus tracking, enabling identification of 7 elements with rapid FISH rounds and a registration algorithm.