H. Liu

This study shows ghrelin prevents white adipose tissue inflammation and atrophy in cancer cachexia, but GHSR-1a is only needed for its appetite-stimulating effect.

This study uses bioinformatics analysis to identify hif-related genes in vhl-deficient cells under hypoxia, finding both up- and down-regulated genes.

The paper introduces PACPIC, a method using phase separation to identify direct and indirect protein-protein interactions in cells by recruitment as a readout.

This study identifies how abnormal nitration and S-sulfhydration of the Sp1-CSE-H2S pathway contribute to the progression of hyperhomocysteinemia through a self-reinforcing cycle.

This paper introduces lipid-mediated insertion of TLR ligands as a non-genetic method to engineer immune cells, showing controlled delivery and persistent activation without permanent genetic modification.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study shows that β-adrenergic receptor signaling regulates cardiomyocyte cytokinesis, and β-blockers like propranolol can enhance division in ToF/PS cardiomyocytes, potentially improving heart function in CHD patients.

This paper introduces a multi-dimensional separation method for glycosaminoglycan oligosaccharides that enables structural and functional analysis without desalting.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

This paper develops an intravital imaging platform to study P. falciparum sporozoite motility in human skin xenografts and tests interventions against malaria sporozoites.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

This study shows calcineurin and Hog1 coordinate to control the cell cycle during stress by modulating transcription factors at multiple regulatory nodes.

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

This study examines the energetics and stability of fish schooling using simulations, finding that energy expenditure and stability influence swimming patterns and synchronization.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

The paper describes a modified TCA/acetone precipitation method for plant protein extraction that is faster and reduces protein degradation compared to traditional methods.

This study examines how biogas slurry affects soil nutrients and economic traits of Camellia oleifera fruits, finding that higher application rates improve soil fertility and fruit yield.

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

The paper identifies toxic inorganic ions that inhibit sensitive microorganisms and favor Rhodanobacter in a metal-contaminated aquifer.

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

This paper shows that transmural mean hoop stress of the aortic wall can be calculated from in vivo images using thin-walled models without needing patient-specific material properties or residual deformations.

This study shows that Bacillus cereus YL6 promotes growth of soybean, wheat, and Chinese cabbage by solubilizing phosphorus and producing plant hormones, while also colonizing plant roots.