J. Si

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Molecular Weight-dependent Diffusion, Biodistribution, and Clearance Behavior of Tetra-armed Poly(ethylene glycol) Subcutaneously Injected into the Back of Mice

This study examines how molecular weight affects the diffusion, biodistribution, and clearance of four-armed PEGs injected subcutaneously into mice.

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

A novel Phytophthora sojae effector PsFYVE1 modulates transcription and alternative splicing of immunity related genes by targeting host RZ-1A protein

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.