P. Singh

This paper establishes a new in vitro and in vivo model using Babesia duncani to study parasite development, virulence, and drug susceptibility, identifying effective new therapies.

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

This study shows that PC-1 and PC-2 form a complex in endothelial cells that mediates flow-induced vasodilation through Ca2+ influx and NOS activation.

This study characterizes Rv0792c, a GntR homolog from M. tuberculosis, identifies small molecule inhibitors, and reveals its role in stress adaptation and virulence.

This paper creates a meta-atlas of human liver immune cells using scRNA-seq data to define immune homeostasis features and identify pathway differences across studies.

This study shows that aggregated Mycobacterium tuberculosis causes more severe lung disease in rabbits by increasing bacterial growth and inflammation compared to single-cell infections.

This study examines how past logging and ongoing anthropogenic disturbances affect vegetation in Himalayan Foothills, finding that selective logging promotes secondary forest features but CAD reduces native diversity and facilitates invasions.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

The paper investigates intergenerational effects of parental larval starvation on offspring traits and gene expression in Athalia rosae, finding trait-dependent effects and gene-level changes.

This study identifies and characterizes novel plasma proteins differentially expressed in drug-resistant HIV/AIDS patients using SWATH-MS.

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

The paper identifies antagonistic roles of CBX2 and CBX7 in breast cancer metabolism using multi-omics data and validates their impact on tumor aggressiveness and drug response.

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

The paper investigates how C4 gene expression is induced through cis-regulatory changes in Gynandropsis gynandra, showing similar induction patterns to C3 genes but with stronger expression.

The paper examines sex allocation plasticity in Macrostomum flatworms, finding self-fertilization predicts plasticity in response to mating partners, not mating strategy.

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

This study uses carnivores in India to assess conservation priorities by integrating ecological, social, and economic factors, identifying gaps in current protected areas and suggesting alternative strategies.

This study shows Ki-67 enables cellular plasticity across tumourigenesis stages, with knockout inhibiting tumour growth and metastasis through transcriptome remodelling and angiogenesis disruption.

This study examines mating behavior and hybridization between two closely related flatworm species despite differences in reproductive morphology and behavior, finding that while they can hybridize, postmating barriers and mating rate differences exist.

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

This study examines how temperature and host plant quality interact to affect life-history traits in the butterfly Bicyclus anynana, revealing complex temperature and sex-dependent effects.

The paper derives a general rule for species coexistence modulated by higher order interactions using a three-species Lotka-Volterra model and extends it to multispecies communities.

This study identifies gene and metabolic signatures in hexaploid wheat roots under iron starvation, revealing key transporters and metabolites involved in Fe acquisition and response.

The paper shows Polo kinase and Centrobin relocalize from mother to daughter centrioles in fly neural stem cells during mitosis, establishing centrosome asymmetry that primes biased MTOC activity.

The paper identifies genome-wide transcription factor binding in leaves of C3 and C4 grasses using DNaseI-SEQ, revealing conserved sites and shared mechanisms in C4 photosynthesis gene regulation.

This study shows HSET forms MT asters using soluble tubulin, not pre-formed MTs, and proposes a model where tubulin availability governs aster versus bundle formation.

The paper identifies natural variation in C4 photosynthesis traits within Gynandropsis gynandra, suggesting adaptation for water use efficiency rather than carbon fixation.

This paper identifies WhiB4 as a redox-dependent nucleoid condensing protein in Mtb that links oxidative stress response with genome organization and gene expression.