S. Lee

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.

This paper shows that RB1 inactivation leads to retinoblastoma in human cone precursors at specific developmental stages, but not in mouse cone precursors, highlighting species-specific differences in tumor genesis.

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.

This paper develops a CRISPR/Cas9 gRNA array system to enable efficient multiplex genome engineering by delivering up to 10 gRNAs as a single transcript.

This paper introduces a 3D model to study GBM invasion mechanisms, showing that topography influences invasion patterns and morphology.

This study shows that BCI induces apoptosis in NCI-H1299 lung cancer cells via the intrinsic pathway by increasing Bax, caspase-9/3, and cytochrome c release while decreasing Bcl-2.

This study shows HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction, revealing a noncanonical role for HSP90 in modulating HSF1 activity by removing HSF1 trimers from DNA.

This study identifies somatic mutations in peripheral blood that predict acute myeloid leukemia (AML) years before diagnosis, with TP53 mutations showing the strongest association and earliest onset.

This paper quantifies lipid content in individual microalgal cells using refractive index tomography without chemical extraction.

This study measures 3D refractive index and membrane properties of live erythrocytes from Pelophylax nigromaculatus to compare interspecific differences with mammals.

This study identifies antibodies from autocrine libraries that can replace reprogramming factors like Sox2 and Oct4, enabling iPSC generation through membrane-initiated signaling pathways.

This study uses optical diffraction tomography to image gold nanoparticles in live cells with high resolution and minimal phototoxicity.

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.

This study identifies non-activated lymphocyte subtypes using label-free refractive index tomography and machine learning with high specificity and sensitivity.

This study examines melittin's effects on human red blood cells using quantitative phase imaging, revealing morphological, biochemical, and mechanical changes.

This study uses 3-D quantitative phase imaging to analyze morphological, biochemical, and mechanical properties of red blood cells from diabetic and non-diabetic patients, finding reduced sphericity, higher haemoglobin content, and lower membrane deformability in diabetic RBCs.