Y. Zou

This study shows that intermittent anti-PI3K treatment can overcome immune checkpoint therapy resistance in Pten-null prostate cancer by converting 'cold' tumors into T cell-inflamed ones.

The paper describes the isolation and characterization of a new butyric acid-producing bacterium from human feces, and reclassifies another species within the same family.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

This paper identifies functional succinate dehydrogenase deficiency and loss of SLC23A1 as common adverse features in clear cell renal cell carcinoma, with implications for diagnosis and treatment.

This paper introduces a method to detect O-GlcNAc modifications using tandem glycan labeling and fluorescent detection, showing HIF1α as an O-GlcNAc target.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study shows a ketogenic diet reduces insulin and inhibits breast cancer growth in mice, with enhanced effects when combined with rapamycin.

The paper introduces PALP, an imaging method that detects and quantifies polyunsaturated phospholipids by inducing peroxidation with laser pulses, enabling non-invasive monitoring of lipid unsaturation and ferroptosis in live cells.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

This study uses internet search data to show seasonal variation in cancer recurrence queries, with peaks in early summer (northern hemisphere) and late summer (southern hemisphere).

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

The paper curates a database of phage-host receptor interactions and finds that viral receptors, both in phages and mammalian viruses, are central in host protein-protein interaction networks.

The paper compares selection pressures on human genes in cancer and normal cells using mutation-profile-based methods, finding differences in selection pressures and their impact on cancer gene classification.