B. Hu

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

This study shows that evolutionary arms race between bat SARSr-CoV spike proteins and ACE2 drives genetic diversity, with SARSr-CoV spike proteins showing higher binding affinity to human ACE2 than bat ACE2.

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

Ilomastat improves mouse survival after irradiation by enhancing hematopoietic recovery through reduced inflammation and increased stem cell counts.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

This study shows that PCH2-mediated dissociation of ASY1's HORMA domain from its closure motif is essential for nuclear targeting and chromosomal loading, while the closure motif is also required for PCH2-mediated removal later in prophase.

This study presents the first 3D images of COVID-19 lung autopsy tissues using high-resolution cleared tissue microscopy, offering new insights into disease processes contributing to mortality.

This study shows pen-strep increases macrophage stiffness and promotes cell spreading on various ECM substrates through YAP-1/TAZ upregulation and β1 integrin downregulation.

This study shows zebrafish shoals exhibit color preferences that are lost in individuals, suggesting social interaction influences innate color preference, possibly via the dopaminergic system.

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study shows that amphipathic helices from cellular proteins can replace the M2 helix in Influenza A virus with minimal effects on replication, but deletion or non-curvature-inducing substitutions prevent virus generation.

This study shows that CHL1 overexpression reverses chemoresistance to cisplatin and paclitaxel in lung cancer by inhibiting the Akt pathway.

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

This study uses cryo-electron tomography to visualize the Salmonella-host cell interface mediated by the type III secretion system, revealing the translocon's structure and its role in effector translocation.

This paper validates antibodies for quantitative western blotting using microwestern arrays, finding many antibodies suitable for quantitative use and demonstrating scalability to standard western blots.

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.