J. O'Sullivan

Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.

Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A

The paper identifies chromothripsis-induced amplification of DYRK1A in blast phase MPN as a driver of aggressive disease and a potential therapeutic target.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

This study identifies plasma proteins associated with response to chemotherapeutic treatment in oesophageal adenocarcinoma using SWATH-MS and ELISA.

Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201

This study investigates how radiation and ONC201 modulate the unfolded protein response (UPR) in prostate cancer cells, enhancing cell death and radiosensitivity.

Morphological variability in the mucosal attachment site of Trichuris muris revealed by X-ray microcomputed tomography

This paper uses X-ray microCT to reveal morphological variability in Trichuris muris attachment sites, showing tunnel structures that contact host immune compartments and vary in length and integrity.

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease.

The paper uses scRNA-seq to study kidney disease progression and regression, identifying new myeloid cell subtypes and their roles in injury and repair.

Microbial and autoantibody immunogenic repertoires in TIF1γ autoantibody positive dermatomyositis

This study identifies expanded microbial and autoantigen antibody repertoires in TIF1γ-positive dermatomyositis, revealing viral enrichment and epitope homology with TRIM proteins.

KH-type splicing regulatory protein controls colorectal cancer cell growth and modulates the tumor microenvironment

This study investigates KHSRP's role in colorectal cancer, showing it promotes tumor growth and modulates the tumor microenvironment through mechanisms involving cell proliferation and angiogenesis.

Single-cell analyses reveal aberrant pathways for megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours

This study shows that Q8, a modified quininib, inhibits colorectal cancer growth and angiogenesis by targeting the TIE-2 signaling pathway in both cell and xenograft models.

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific genetic changes associated with immortalisation and malignancy.

This study identifies stage-specific genetic changes in head and neck squamous cell carcinoma progression, highlighting CSMD1 inactivation as a key factor in early carcinogenesis and metastasis.

A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression

This study identifies a genetic variant linked to serum urate levels and shows it enhances HNF4A-dependent PDZK1 expression, potentially increasing urate transport.