LRG1 promotes atherosclerosis by activating macrophages
J. Wang, S. Zhang, J. Wang, J. Zhong, H. Liu, W. Li, M. Chen, L. Xu, W. Zhang, Z. Zhang, Z. Wei, J. Guo, X. Wang, J. Sui, X. Liu, X. Wang
This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.
bioRxiv · Jan 23, 2024 · PreprintPathology