J. Ye

This study investigates how the herbal medicine Kursi Wufarikun Ziyabit inhibits mitochondrial ATP production, activates AMPK, and induces FGF21 expression in hepatocytes, suggesting a mechanism for its therapeutic effect in type 2 diabetes.

This study shows that reduced IF1 in obesity leads to mitochondrial reprogramming through ANT2 downregulation, improving insulin sensitivity despite increased body weight on a high-fat diet.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

This paper shows how Begomovirus uses a phosphatase to suppress plant immunity, enhancing virus transmission by herbivore vectors.

This study shows that NRT1.1 in Arabidopsis roots coordinates with K+ channels to regulate uptake and allocation of potassium.

This study validates DEXA as a longitudinal measure of lean body mass and skeletal muscle wasting in a PDAC mouse model.

This study identifies novel respiratory strategies in Methanoperedenaceae archaea acquired through lateral gene transfer, expanding their metabolic flexibility in anaerobic methane oxidation.

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

This study demonstrates that low intensity pulsed ultrasound selectively disrupts cancer cells by exploiting their distinct mechanical properties, offering a safer alternative to high intensity ultrasound ablation.

This study identifies miR-466d-3p as a target of JEV NS3 that regulates IL-1β and viral replication through miRNA degradation.

This study estimates that ultra-rare variants contribute significantly to cis-heritability of gene expression, with singletons accounting for ~25% and most of that from variants absent in thousands of samples.

The paper identifies Dnmt3aos as a lncRNA regulating Dnmt3a expression and DNA methylation in macrophage polarization, revealing its role in modulating IFN-gamma expression.

This study shows autophagy promotes osimertinib resistance in EGFR-mutant lung cancer by enhancing stem-cell like properties, and inhibiting autophagy reverses resistance.