L. Yu

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

This study investigates how Oreorchis patens responds to cold stress by analyzing physiological, biochemical, and molecular mechanisms, identifying differentially expressed genes and confirming their roles through qRT-PCR.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This study investigates how tetraspanin 4 mediates migrasome formation through a two-stage mechanism involving membrane tension and cholesterol.

The paper identifies a regulatory mechanism linking drought stress and fiber yield in upland cotton through the interaction of GhHSFA6B-D and GhIPS1-A, showing conservation in Arabidopsis.

This study shows that tetraspanin4 and CD9 sense positive membrane curvature, revealing their role in membrane shaping processes like migrasome formation and oocyte microvilli shaping.

IDPConformerGenerator generates diverse ensembles of disordered protein states using physical restraints and machine learning, enabling structural analysis of intrinsically disordered proteins.

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study identifies factors influencing immunopeptidome remodeling by IFN-gamma in colorectal cancer, revealing proline's role in peptide downregulation on HLA-I.

This study predicts the conformational dynamics, shapes, and contact propensities of intrinsically disordered proteins using advanced molecular dynamics simulations.

This study identifies AHR's role in regulating intrinsic immunity, proliferation, and migration in GBM stem cells and organoids, linking it to poor prognosis and suggesting it as a therapeutic target.

The paper introduces a method to detect clonemates in multicellular clonal species using Shared Heterozygosity (SH) and technical replicates, showing its effectiveness in seagrass clones.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

This paper develops a deep learning framework to denoise Monte Carlo photon transport simulations, significantly improving image quality and reducing computational costs.

This study investigates MCT deficiency in Syrian hamsters infected with SARS-CoV-2, finding a 67% reduction in MCT rate by 2 dpi due to decreased motile ciliation.

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

The paper identifies ANTH domains in CALM, HIP1R, and Sla2 that bind ubiquitin, contributing to clathrin-mediated endocytosis of ubiquitinated membrane proteins.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This paper demonstrates a method for unidirectional transport of full-length proteins through nanopores using guanidinium chloride and machine learning to identify protein orientation and identity.

This study converts octameric MspA into single-chain pores to improve DNA sequencing accuracy by enabling controlled subunit stoichiometry and pore geometry.

The paper challenges the claim that HPV16 circular RNA circE7 drives cell transformation, showing its low abundance and attributing observed effects to off-target siRNA effects on linear E7 mRNAs.

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

The paper shows that loss of KMT5B in DIPG cells depletes retained H3K27me3 loci, leading to transcriptional changes that promote tumorigenesis.

The paper uses a land surface model and foliar nitrogen isotope data to assess global nitrogen limitation, finding that leaf δ15N trends cannot alone determine nitrogen limitation and that model integration reveals underlying drivers.

The paper uses RNA-seq to show that GmSALT3 improves ROS detoxification in salt-stressed soybean roots by enhancing antioxidant activity and related pathways.

The paper identifies CSA1 as a TIR-NBS-LRR protein required for autoimmune cell death in Arabidopsis when BAK1 and BIR3 are mutated, linking BAK1 to NLR proteins in immune responses.