S. Singh

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

This study shows that obese female mice have suppressed vascular Rho-kinase activation, which protects against cardiovascular issues, unlike male mice.

The paper describes the design and synthesis of a mitoxantrone-biotin probe (MXP) to identify and characterize cellular targets of mitoxantrone, demonstrating its ability to isolate RAD52.

The paper shows that BOD1L in the SETD1A complex maintains DNA repair gene expression despite reducing H3K4 trimethylation, and its loss causes DNA damage and cell death in ESCs.

This paper develops a recombinant spike protein subunit vaccine (IMT-CVAX) against SARS-CoV-2 that elicits broad neutralization against variants and provides protection in animal models.

This study shows that progranulin regulates blood pressure and vascular tone through EphrinA2, Sortilin1 receptors, and eNOS activation, with PGRN deficiency causing hypertension and vascular dysfunction.

This paper develops a prodrug strategy to overcome phenotypic AMR in Mtb by enhancing drug permeability and targeting hypoxic persisters.

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

This study identifies sampling challenges in protein:protein binding free energy calculations and demonstrates how to overcome them using alchemical methods and long simulations.

This paper develops two platforms to create chimeric small molecules that induce tyrosine phosphorylation, demonstrating their ability to trigger phosphorylation and biological activities in target proteins.

This study characterizes the pharmacological response of the GRABeCB2.0 sensor to endocannabinoids and cannabinoids, finding that its EC50 values for 2-AG and SR1 match CB1R potencies, while others show lower EC50s, and CBD acts as a negative allosteric modulator.

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

This study identifies a multi-receptor complex involving c-Met, E-cadherin, and EGFR that C. albicans uses to invade oral epithelial cells, with Hyr1 and Als3 facilitating this process and dual inhibition of c-Met and EGFR reducing virulence.

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

This study characterizes a matured HIV-1 broadly neutralizing antibody from a pediatric donor, showing improved neutralization breadth and potency through structural analysis.

This paper presents a method to improve kinase inhibitor selectivity by combining inhibitors with divergent off-target activities, validated using a NanoBRET assay.

The paper designs a chimeric peptide that inhibits Plasmodium falciparum red blood cell invasion with 100x higher efficacy than its parent peptides.

This study shows that stromal compartments in a mouse model of BPH are resistant to castration-induced regression, suggesting the need for additional therapies.

This study shows that a custom-designed PPR protein knocks down mitochondrial atp1 mRNA, reducing F1Fo ATP synthase, plant growth, and amino acid metabolism in Arabidopsis.

The paper examines antibody diversity in an unvaccinated SARS-CoV-2 infected individual, finding that post-vaccination neutralization breadth against Omicron variants is comparable to vaccinated individuals and breakthrough infections.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

This study investigates why amyloid-β plaques in Alzheimer's Disease are visible in X-ray phase-contrast imaging, finding that metal entrapment, not fibrils, drives the contrast in transgenic rodents and human genetic cases.

This paper develops a size-tunable ICG-based contrast agent for NIR-PAI, showing enhanced in vivo imaging of liver and spleen with high photostability and targeting ability.

This study examines vascular function and blood pressure in a mouse model of Kawasaki disease, finding vascular dysfunction linked to COX-derived products, oxidants, and NO bioavailability.

This study evaluates Gepotidacin's activity against drug-resistant mycobacteria, showing potent in vitro and in vivo efficacy, resistance bypass, and synergistic potential.

The paper shows glucocorticoids enhance CD8+ T cell memory differentiation by promoting tissue-homing TRM cells and metabolic shifts via AMPK and STAT3/5 signaling.

This study investigates psilocybin's effect on marble-burying in mice, finding that 5-HT1A receptors mediate some effects but not the primary action, and that buspirone may block psychedelic effects without affecting anti-obsessional effects.

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.