Author

X. Gui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Plant Biology· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Organism:Arabidopsis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Schnittger· 2 shared B. Liu· 2 shared C. Wang· 2 shared H. Fu· 2 shared J. Zhao· 2 shared M. Zhang· 2 shared Z. Ren· 2 shared A. Singh· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPlant Biology

A. Schnittger

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

J. Zhao, H. Fu, Z. Wang, M. Zhang, Y. Liang, X. Cui, W. Pan, Z. Ren, Z. Wu, Y. Zhang, X. Gui, L. Huo, X. Lei, C. Wang, A. Schnittger, , B. Liu

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

bioRxiv · Jul 16, 2024 · PreprintPlant Biology

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

T. Das, F. Zaidi, M. Farag, K. M. Ruff, T. S. Mahendran, A. Singh, X. Gui, J. Messing, J. P. Taylor, P. R. Banerjee, R. V. Pappu, T. Mittag

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

bioRxiv · Feb 28, 2024Biophysics

ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature

J. Zhao, X. Gui, Z. Ren, H. Fu, C. Yang, Q. Liu, M. Zhang, W. Wang, C. Wang, A. Schnittger, B. Liu

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

bioRxiv · Sep 29, 2022Plant Biology

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

Z. Shan, L. Li, C. L. Atkins, M. Wang, Y. Wen, J. Jeong, N. Moreno, D. Feng, X. Gui, N. Zhang, C. G. Lee, J. A. Elias, W. Lee, B. Gao, F. W. Lam, , C. Ju

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

bioRxiv · Apr 8, 2021Pharmacology & Toxicology

An antibody-dependent enhancement (ADE) activity eliminated neutralizing antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

X. Gui

This study develops a modified monoclonal antibody MW05/LALA that eliminates ADE activity and shows strong prophylactic and therapeutic effects against SARS-CoV-2 in rhesus monkeys.

bioRxiv · Jul 26, 2020 · PreprintMicrobiology

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

Y. Sun, K. Zhao, W. Xia, J. Gu, Y. Ma, X. Gui, X. Zhang, Y. Fang, B. Sun, C. Liu, D. Li

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

bioRxiv · Jun 5, 2020Biophysics