C. Duan

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

This paper presents a 3D-printed composite scaffold system for bone regeneration that accelerates ECM and mineralized osteoid deposition in vivo.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty

This paper develops a drug-eluting bioresorbable vascular scaffold with reduced strut thickness and controlled drug release, showing comparable pre-clinical performance to metallic stents.

Diversity of Bathyarchaeia viruses in metagenomes and virus-encoded CRISPR system components

The paper identifies 56 metagenome-assembled genomes of Bathyarchaeia viruses and describes their CRISPR system components, revealing potential counter-defense mechanisms.

FK506 binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium

This study identifies Fkbp5 as a regulator of epithelial cell quiescence-proliferation transition via Akt signaling in zebrafish using transcriptomics and genetic approaches.

Local administration of a novel siRNA modality into the CNS extends survival and improves motor function in the SOD1G93A mouse model for ALS

This study demonstrates that a novel siRNA modality, conjugated with an accessory oligonucleotide, improves survival and motor function in a mouse model of ALS when delivered locally to the CNS.

ROS signaling-induced mitochondrial Sgk1 regulates epithelial cell plasticity

This study identifies a mitochondrial signaling loop involving Sgk1 that regulates epithelial cell plasticity in zebrafish and human cancer cells.

The TaxUMAP atlas: efficient display of large clinical microbiome data reveals ecological competition involved in protection against bacteremia

The paper introduces TaxUMAP, a visualization tool for microbiome data, revealing that Klebsiella species reduce bacteremia risk through competition with other pathogens.

Computationally Guided Design of BCR-ABL Tyrosine Kinase Inhibitors

The paper designs two new BCR-ABL tyrosine kinase inhibitors with predicted improved binding affinity over imatinib for advanced chronic myeloid leukemia treatment.