J. Zhan

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Comparative RNA profiling identifies stage-specific phasiRNAs and co-expressed Argonaute genes in Bambusoideae and Pooideae species

The paper identifies stage-specific phasiRNAs and co-expressed Argonaute genes in Bambusoideae and Pooideae grasses, revealing conservation and differences in their biogenesis and targets.

An experimental approach to study multi-species interactions implicated in Fusarium-Head Blight complex assembly in wheat.

This paper presents an experimental approach to study multi-species interactions in the Fusarium-Head Blight complex in wheat, showing that Zymoseptoria tritici affects wheat's response to F. graminearum and that Fusarium species composition influences disease outcomes in a genotype-specific manner.

Premeiotic 24-nt phasiRNAs are present in the Zea genus and unique in biogenesis mechanism and molecular function

The paper identifies premeiotic 24-nt phasiRNAs in maize and related species, showing they are distinct from meiotic 24-nt phasiRNAs in biogenesis and function.

Assembly of mTORC3 involves binding of ETV7 to two separate sequences in the mTOR kinase domain.

This study identifies mTORC3, a rapamycin-resistant mTOR complex that requires ETV7 binding, and shows that specific mTOR and ETV7 domains mediate this interaction, with implications for cancer therapy.

mTORC3 activity is regulated by GSK3β through the activation of PKCδ that phosphorylates and activates STAT1.

The paper identifies a novel GSK3β/PKCδ/STAT1 pathway that regulates ETV7 transcription and mTORC3 activity in Karpas cells.

Diagnostic of head blight and leaf blotch diseases of wheat in Sweden using a mycobiome isolation approach

The paper surveys wheat pathogen diversity in Sweden to improve disease diagnostics and management by identifying pathogenic and non-pathogenic taxa and potential biological control agents.

Temporal Transcriptome Analysis Uncovers Regulatory Modules Programming Embryo Development from Embryonic Morphogenesis to Post-Germination

The paper profiles soybean seed embryo transcriptomes across development to identify gene functions and regulatory networks involved in reserve accumulation and germination.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

The cryptic step in biogeochemical Tellurium (Te) cycle: Indirect elementary Te oxidation mediated by manganese-oxidizing bacterium (MnOB)

This paper identifies a previously overlooked process where manganese-oxidizing bacteria oxidize elemental tellurium, challenging the assumption of Te0 stability in wastewater treatment.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

Important Role of Hematopoietic Proteoglycan Serglycin in Liver Hepatocellular Carcinoma Associated with Tumor Microenvironment

This study investigates the role of Serglycin in liver hepatocellular carcinoma, showing its association with tumor microenvironment and prognosis.

Phylogenetic analyses of AGO/DCL/RDR proteins in green plants refine the evolution of small RNA pathways

This study performs phylogenetic analyses of AGO/DCL/RDR protein families across 196 green plant species to refine the evolutionary history of small RNA pathways.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

The Biogeography of Fungal Communities Across Different Chinese Wine-producing Regions Associated with Environmental Factors and Spontaneous Fermentation Performance

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

Listeria monocytogenes personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens

This study demonstrates that ADXS-NEO, a personalized Listeria monocytogenes vaccine, effectively targets tumor-specific mutations and controls tumor growth in mice by inducing neoantigen-specific T cell responses.