Z. Liao

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Brochosomes as an antireflective camouflage coating for leafhoppers

This study identifies brochosomes as an anti-reflective nano-coating in leafhoppers, revealing their structural proteins and evolutionary origin.

Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

Cross-continental variation of herbivore resistance in a global plant invader

The paper examines genetic differentiation in herbivore resistance traits among native and introduced populations of Japanese knotweed across different regions.

Evolution of microRNAs in Amoebozoa and implications for the origin of multicellularity

The paper identifies miRNAs in Amoebozoa, showing they are present in unicellular and multicellular species, but not required for multicellularity evolution.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

Longitudinal characterization of circulating extracellular vesicles and small RNA during simian immunodeficiency virus infection and antiretroviral therapy

This study tracks changes in extracellular vesicle concentration and small RNA expression during SIV infection and ART in macaques, identifying dynamic shifts in miRNAs and U6 RNA associated with viral load.

Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platform

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

Environmental stress determines the colonization and impact of an endophytic fungus on invasive knotweed

This study shows that the endophytic fungus S. herbamans colonizes invasive knotweed under stress but affects growth differently depending on environmental conditions.

Transferrin receptor is another receptor for SARS-CoV-2 entry

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

Lateral mechanical impedance rather than frontal, promotes cortical expansion of roots

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

Abundantly expressed class of non-coding RNAs conserved through the multicellular evolution of dictyostelid social amoebae

The paper identifies and characterizes Class I non-coding RNAs in dictyostelid social amoebae, showing their conservation and potential role in multicellular development.

Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance

The paper shows that commensal microbes up-regulate host transferrin to suppress TLR signaling and promote immune tolerance in the gut.

High standing genetic variation in an invasive plant allows immediate evolutionary response to climate warming

This study shows that invasive common ragweed populations can rapidly evolve in response to climate warming within a single generation, with greater genetic divergence and phenotypic convergence under warming conditions.

Phytophthora infestans Ago1-bound miRNA promotes potato late blight disease

This study identifies a P. infestans miRNA that targets a potato gene, promoting late blight disease by modulating host mRNA expression.

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus