T. Jiang

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

The paper introduces a database to analyze the nucleating properties of Crystallophore proteins and compares Tb-Xo4 with Lu-Xo4 for improved phasing.

The paper develops CM93, a novel EGFR inhibitor with improved targeting and brain penetration, showing better efficacy and safety in mouse models of EGFR-mutant NSCLC and brain metastases.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This study uses molecular dynamics simulations to show how AP sites in nucleosomal DNA exhibit distinct dynamics and increased DNA-protein cross-link formation compared to tetrahydrofuran analogs.

This study shows that Gdh2-dependent alkalization is not required for C. albicans to escape macrophages or maintain virulence, challenging the existing model of amino acid catabolism in phagosomes.

The paper presents a 2.6 Å structure of a CLC mutant, revealing a global conformational change that supports a unified transport mechanism for CLC proteins.

This study compares clathrin-mediated endocytosis in budding and fission yeast, finding conserved mechanisms and species-specific adaptations in actin assembly and membrane invagination.

The paper curates a database of phage-host receptor interactions and finds that viral receptors, both in phages and mammalian viruses, are central in host protein-protein interaction networks.

This study identifies three PI(4,5)P2 binding sites on ANO1 that allosterically regulate its Ca2+-activated Cl- channel gating through molecular dynamics and electrophysiology.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

This paper introduces an adaptive geometric search algorithm for macromolecular scaffold selection, improving efficiency in matching functional motifs to protein surfaces.