X. Xie

This paper develops a PCR-based SARS-CoV-2 replicon system for antiviral screening, showing robust replication and inhibition by remdesivir.

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

The paper designs ACE2-Fc variants with lost enzymatic activity but retained antiviral function to avoid cardiovascular side effects.

The paper shows that natural feeding patterns do not synchronize peripheral clocks, as clock phases are better predicted by rest-activity cycles than food schedules.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

The paper designs a soluble ANGPT1 mimetic, C4BP-ANG1, which activates Tie2 and reduces vascular leakage in models of inflammation.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.

The paper identifies hydroxyl carlactone derivatives as the main strigolactones in Arabidopsis, showing their biosynthesis via MAX1 and LBO enzymes.

This study identifies LjMAX1 as the key enzyme in Lotus japonicus strigolactone biosynthesis, showing it converts carlactone to 18-hydroxycarlactonoic acid, a precursor for both canonical and non-canonical strigolactones.

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study shows BRD2 and SREBP2 work together to increase sigma-2 receptor expression when cells lack cytosolic cholesterol.

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.

This study creates GH5 cellulase hybrids from mesophilic and thermophilic parents to identify elements enhancing thermostability, finding improved thermal properties in some hybrids.

This study shows that anxiety from BDNF deficiency in specific brain regions increases energy expenditure and reduces diet-induced obesity.

This paper describes the fusion of DN and AflR genes to create a novel protein that enhances anti-A. flavus activity compared to DN alone.

The paper compares canonical and non-canonical strigolactones, showing non-canonical ones are major germination stimulants in root exudates and likely the true shoot branching inhibitors.