D. Kim

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

This study compares RF-induced heating of cardiac implantable electronic devices in adult and pediatric phantoms with epicardial and endocardial leads, finding significant differences in heating based on age and lead configuration.

This paper modifies a blood-based ELISA to a salivary-based ELISA for TNF-alpha quantification in IBD, finding reduced sensitivity but improved accessibility.

This study shows MLL1 promotes cancer metastasis by regulating cytokine secretion and actin dynamics, and its inhibition reduces metastasis when combined with chemotherapy.

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

This study characterizes the amyloidogenic properties of a self-assembling peptide and demonstrates its safety and adjuvant potential as a DNA vaccine platform.

The paper develops a microfluidic immuno-serology assay to analyze immune responses in patients with altered immunity, finding reduced diversity in protein cooperation and impaired antibody responses in certain groups.

This study shows that low lamin A levels in breast cancer cells increase nuclear deformability and metastatic capacity, with lower lamin A levels linked to poorer disease-free survival in human tumors.

This study shows that modifying epicardial lead trajectories can significantly reduce MRI-induced RF heating in pediatric patients with cardiac implants.

The paper uses ddRAD sequencing and CT scans to identify a second species in the ancient Bowfin lineage, dating diversification to the Pleistocene.

The paper identifies 356 PAR-binding proteins using a human protein microarray, revealing new biological roles of PARylation beyond DNA repair.

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

This study identifies ILK5 as a downstream substrate of P2K1 kinase that mediates MAPK cascade activation in Arabidopsis, enhancing innate immunity through phosphorylation of MPK3/6.

This study identifies G23Rik as a PPAR-regulated lncRNA that reduces hepatic lipid accumulation during fasting.

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

This study identifies Ifit2 as a regulator of myeloid cell activation and metabolic activity, which limits autoimmune inflammation in EAE.

The paper examines gene flow and reproductive isolation in Rumex hastatulus hybrid zones, finding that the neo-X chromosome contributes to inter-cytotype differentiation.

This study identifies lncRNA152 as an angiogenesis-inhibiting tumor suppressor in TNBC that upregulates RBM47, reducing cancer aggressiveness.

This study uses top-down mass spectrometry to analyze O-glycoform changes in the Omicron S-RBD variant compared to wild-type and Delta, revealing novel glycosites and structural heterogeneity.

This study shows that a single intramuscular dose of MBP431, a modified ebolavirus therapeutic, can reverse disease and provide protection in non-human primates.

This study shows that IL-30, a subunit of IL-27, has a regulatory role in autoimmune inflammation, with its expression by APCs limiting inflammation, while dendritic cell-derived IL-30 is not required for disease development.

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

The paper describes a patient-driven initiative that collects clinicogenomic data from metastatic prostate cancer patients, revealing consistent patient-reported data and genomic insights from cfDNA samples.

This study examines co-infection and super-infection dynamics of Mayaro and Zika viruses in mosquito and vertebrate cells, finding negative impacts on Zika replication and transmission.

The paper identifies consistently expressed genes in pancreatic ductal adenocarcinoma (PDAC) to prioritize therapeutic targets and biomarkers.

This study shows Salmonella Typhimurium uses propionate as a carbon source for anaerobic respiration to overcome colonization resistance in the gut.

The paper investigates how glycan-lectin communication pathways transmit information, finding that dectin-2 is an inefficient receptor but its signal can be enhanced by co-receptor overexpression.