G. Yu

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

This study examines splenomegaly, histopathology, and splenocyte composition in mice infected with Plasmodium berghei K173, showing strain-specific differences in parasite control and splenic function.

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

This study shows that the bacterial effector RipAC targets PUB4 to inhibit PTI by disrupting BIK1 homeostasis.

This study identifies a metabolic pathway involving pyruvate decarboxylases that contributes to plant resistance against bacterial wilt disease, and shows how a bacterial effector inhibits this pathway to promote disease.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

This study shows that SGT1 is not required for bacterial PAMP-triggered immunity in Nicotiana benthamiana and Arabidopsis.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

This paper investigates how perturbing GABA biosynthesis in Arabidopsis affects leaf development by linking it to endoreplication and cell expansion.

This study identifies RipAC, a bacterial effector that inhibits SGT1 phosphorylation by blocking its interaction with MAPKs, thereby suppressing plant immunity.

This study investigates how Ralstonia solanacearum uses effector proteins to elicit and suppress plant immunity in Nicotiana benthamiana.

This paper develops and validates a Quantitative Dot Blot (QDB) method for absolute quantification of Her2 in FFPE breast cancer tissues, showing high correlation and diagnostic accuracy comparable to IHC and FISH.

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

The paper assesses RNA folding specificity in mRNA and noncoding RNA, finding that specific folding is more evolutionarily adaptive and functionally significant.

This study infects marmosets with Zika virus and finds they exhibit key features of human disease, including asymptomatic infection and viral persistence in lymph nodes.

The paper predicts that resistance evolution is less likely against antimicrobial peptides compared to antibiotics due to their pharmacodynamic differences, offering a framework for antibiotic stewardship.