J. Wang

The paper investigates the ecological niches of Pristionchus and Panagrellus nematodes, finding they feed on decomposing vegetal matter and are transported by various arthropods, challenging the notion that they are exclusively necromenic.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

The paper analyzes miRNA expression in serum exosomes from healthy controls, latent TB, and active TB to identify differentially expressed miRNAs and their potential roles in TB progression.

This paper conducts a GWAS on the Hybrid Mouse Diversity Panel to identify genetic loci associated with noise-induced cochlear synaptopathy and identifies 4 novel loci and candidate genes.

This study shows that claudin-4 reconstituted in vesicles forms tight interfaces that partition membrane proteins, supporting its role as a molecular fence in epithelial polarization.

The paper develops a gene therapy system that uses telomerase activity to kill cancer cells in mice without affecting normal cells.

This study shows that an immune-responsive retrotransposon in Arabidopsis influences disease resistance gene expression through its LTR.

This study presents the cryo-EM structure of the mouse TRPC4 ion channel, revealing unique features that contribute to its ion selectivity and evolutionary diversity within the TRP family.

This paper introduces a method to infer tumor phylogeny and deconvolute structural variations from bulk genomic data, showing it works well on simulated and breast cancer data.

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

This paper introduces ctPCR, a CRISPR-based method for detecting and typing DNA, validated for HPV subtypes and cervical carcinoma cells.

This study uses GWAS and RNA-Seq to identify genetic differences between lesion and nodal resistance in pea to Sclerotinia sclerotiorum, finding distinct genetic mechanisms for each resistance type.

The paper identifies a major genetic locus, PtFT2, that controls local adaptation and adaptive life history variation in European aspen across a latitudinal gradient.

This study uses microscopy to show RNase E and ribosomes are spatially organized in Caulobacter crescentus, with clustering linked to RNA availability and rRNA gene location.

The paper shows that the functional distinction between β- and γ-actin is determined by their gene sequence, not their protein sequence, through genome editing in mice.

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

This study uses 18F-FDG PET/CT imaging and molecular assays to assess BAT aging in LmnaG609G/G609G mice, finding reduced metabolic activity and increased apoptosis/senescence compared to wild-type mice.

The paper investigates a classic bistable genetic switch in E. coli, revealing new cell fate potentials and switching kinetics beyond the classical two-state model.

This study identifies an RNA-mediated dimerization mechanism that regulates APOBEC3H DNA deaminase activity, localization, and antiviral function.

This study shows type 2 diabetes increases centrosome amplification in PBMCs through AKT-ROS-dependent activation of ROCK1 and 14-3-3σ.

This study identifies a genetic variant affecting telomere length in C. elegans and finds no correlation between telomere length and fitness traits.