J. Zhou

This study identifies four microbial guilds in the rhizosphere and detritusphere of Avena fatua, showing niche differentiation drives carbohydrate depolymerization and soil carbon cycling.

The paper identifies intronic heterochromatin as a mechanism suppressing cryptic transcription initiation by TEs in Arabidopsis.

The paper identifies major clades of large phage genomes across diverse ecosystems and highlights their expanded genetic repertoires and potential functional roles.

This study identifies OsCYP71D8L as a regulator of gibberellin and cytokinin homeostasis in rice, affecting growth and stress tolerance.

CropSurveyor manages and integrates IoT-based crop phenotyping data from distributed sensors, enabling real-time monitoring and historical comparison of crop growth and environmental conditions.

The paper identifies BAP1 loss as a marker for a distinct immunogenic PeM subtype, suggesting potential therapeutic targets like immune checkpoint inhibitors.

This study investigates the effects of fasting caecotrophy on growth performance and lipid metabolism in rabbits using RNA-Seq, finding reduced body weight, lipid droplet accumulation, and altered gene expression related to lipid metabolism.

This paper determines the structural basis for the stereoselective dehydration and hydrogen-bonding catalysis by LepI, revealing how it functions as a multifunctional pericyclase.

This paper introduces a method using tertiary structural motifs to predict and design peptides that bind anti-apoptotic proteins Bfl-1 and Mcl-1 with high accuracy and efficiency.

This paper introduces a protein design framework called dTERMen that uses sequence-structure compatibility patterns from known proteins to generate functional sequences, showing it can produce stable, foldable proteins with desired structures.

This study uses a microvasculature-on-a-chip system to analyze ex vivo dynamics of human glioblastoma cells, showing correlations with tumor heterogeneity and subtypes.

The paper shows that small non-additive contributions to folding free energy are essential for protein stability, compatible with observed additive mutation effects.

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.

This study compares the nuclear export and cargo dissociation mechanisms of RanBP1 in fungi and animals, revealing distinct interactions and complex stoichiometry.

This study identifies clofazimine as a Cx46 inhibitor that targets glioblastoma cancer stem cells by disrupting gap junction communication, enhancing the efficacy of temozolomide.

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.

The paper analyzes the evolutionary ages of cancer-related genes and finds they are enriched for pre-Metazoan genes, suggesting cancer reverts to an ancestral state.

Leaf-GP is an open software tool for automated growth phenotype analysis in plants, capable of processing large image datasets and extracting multiple growth traits from Arabidopsis and wheat.

This paper introduces speed breeding, a method that accelerates crop research and breeding by shortening generation times and enabling more generations per year.

The paper investigates how microbial communities assemble on different soil minerals in the rhizosphere and finds that dispersal limitation and microbial growth capacity shape these communities.

The paper shows PGC-1α and Bcl-2 work together to reduce ROS and delay cell cycle progression in U251 cells after serum depletion.

The paper compares selection pressures on human genes in cancer and normal cells using mutation-profile-based methods, finding differences in selection pressures and their impact on cancer gene classification.