J. Zhou

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

The paper identifies Novobiocin as a POLθ inhibitor that selectively kills HR-deficient tumors, including those resistant to PARP inhibitors.

This paper introduces SPD-NGS, a method using phage display libraries to deeply profile protease substrate specificity, identifying cleavage sites and natural substrates with high coverage and accuracy.

The paper identifies the importomer as the peroxisomal translocase responsible for integrating membrane proteins, showing it operates without substrate unfolding.

The paper spatially maps the human nephrogenic program using single-cell RNA sequencing and generates functional gene-networks to identify developmental disease genes and predict new targets.

The paper demonstrates that microbial communities in in-field bioreactors shift dynamically in response to geochemical perturbations, with significant changes in taxa composition and similarity to contaminated well communities.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study shows switchgrass cultivation increases microbial extracellular polysaccharide (EPS) production and water-stable soil aggregates in marginal soils, driven by root biomass and soil water potential.

This study develops an in vitro model of senescent hepatic cells to investigate metabolic changes in aging, finding altered metabolism, signaling, and toxicity in senescent AML12 cells.

The paper investigates auxin and GA signaling crosstalk in wild strawberry fruit initiation, revealing conserved and novel mechanisms through genome editing and network analysis.

The paper compares silicone and cotton swabs for RNA extraction in COVID-19 testing, finding silicone swabs yield higher RNA concentration and quality.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

This study quantifies FtsZ dynamics in Bacillus subtilis and shows the Min system disassembles Z-rings and inhibits polar peptidoglycan remodeling.

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

This study shows that P16 methylation increases cancer cell sensitivity to palbociclib, a CDK4/6 inhibitor, through experimental and pharmacogenomic analyses.

This study identifies phosphorylation of mitochondrial matrix proteins as a mechanism regulating selective mitophagic degradation in yeast, involving phosphatase Aup1 and kinases Pkp1/Pkp2.

This study uses smFRET to show circovirus capsid undergoes reversible conformational changes, regulated by heparan sulfate and neutralizing antibodies, revealing dynamics in receptor binding.

This paper optimizes violacein extraction and culture conditions in Yarrowia lipolytica to improve yield and purity, establishing a scalable production platform.

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

The paper evaluates sand dune restoration methods on the Zoige Plateau, finding that sandbag and wicker with seeding improved soil conditions more than seeding alone.