R. Zhao

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.

This paper describes a novel Asgard phylum, Sifarchaeota, identified from deep marine sediments, capable of anaerobic methylotrophy and saccharolytic metabolism, with evidence of horizontal gene transfer enhancing its ecological adaptability.

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This study examines how changes in zonular tension affect the subcellular distribution of AQP5 in rat lens water influx and efflux zones, finding that AQP5 shifts from membranous to cytoplasmic under reduced tension.

This study investigates how thermal stress and acrolein, a smoke toxin, affect airway epithelial barrier function by altering ion transport pathways and tight junction integrity.

The paper presents 11 metagenome-assembled genomes of ammonia oxidizing archaea from marine sediments, revealing three independently evolved lineages with specific adaptations to deep-sea conditions.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

This study shows high glucose increases store-operated calcium entry but reduces calcium influx during target recognition in CTLs, leading to increased necrosis after killing.

This paper introduces a light-driven molecular motor system to apply forces to cellular receptors, demonstrating its ability to manipulate cell adhesion and activation.

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

This study shows plasmin cleaves ENaC channels at multiple sites, enhancing fluid clearance in lung injury models.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This study identifies and analyzes new archaeal lineages from deep Costa Rica sediments, revealing novel metabolic capabilities and potential ecological interactions.

The paper reports the in situ growth of anammox bacteria in 80,000-year-old subseafloor sediments, showing increased abundance and genomic evidence of active replication.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

This paper introduces DRRAFTER, a method to model RNA-protein complexes from cryoEM maps, showing it can build accurate RNA coordinates in real-world scenarios.