W. Tang

This study constructs two oncolytic adenoviruses carrying mK5 or MnSOD genes under survivin promoter control and shows their combined use significantly inhibits gastric cancer growth in vitro and in vivo.

This paper identifies Rab5a as a host factor that RSV activates to suppress IRF1-dependent IFN-λ production, thereby reducing antiviral immunity in airway epithelial cells.

This study shows that the FER-pectin complex transduces mechanical forces to regulate cortical microtubule reorganization via ROP6 GTPase signaling in Arabidopsis.

This study shows that green autofluorescence intensity in B16-F10 cells correlates with intracellular oxidative stress and cell death induced by BSO.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This study investigates how cardiomyopathy mutations affect the power stroke of human cardiac myosin using FRET and kinetic measurements, revealing impaired structural changes and reduced force development.

The study investigates SARS-CoV-2 infections in cats and dogs from households with human COVID-19 cases, finding 47.1% of cats and 15.3% of dogs tested positive, with most asymptomatic and viral RNA persistence observed.

This paper identifies rhodomyrtone as a broad-spectrum antiviral with activity against SARS-CoV-2 and other viruses, showing potent antiviral effects and low resistance potential.

The paper shows MCM complexes block cohesin-mediated loop extrusion, reducing CTCF-anchored loops and TAD boundary insulation in G1 phase.

This study identifies lncRNA-RMST as a SOX2 co-regulator that modulates miR-1251 expression, influencing cell proliferation and migration in Hirschsprung's disease.

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

This study investigates how lung cancer increases epidermal green autofluorescence in mice and finds that inflammation is the key driver of this increase.

This study identifies retro-DNAs, a new type of non-LTR retrotransposon derived from DNA transposons, in primate genomes, showing they use the L1 TPRT mechanism and may impact gene function.

This study introduces scsHi-C to analyze sister-chromatid interactions in human chromosomes, revealing frequent contacts at TAD boundaries and dynamic cohesin roles.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

The paper measures absolute copy numbers and dynamics of cohesin, CTCF, and related proteins in human cells, revealing that some genomic enrichment sites are unoccupied in single cells.

This study identifies species-specific mobile elements in eight primate genomes, revealing significant variation in DNA transposition activity and subfamily dominance across species.

The paper identifies 15,463 human-specific mobile elements (HS-MEs) contributing to genome size increase and gene regulation, expanding prior knowledge by over 8,000 elements.

The paper identifies DNA damage repair pathways that reduce formaldehyde toxicity in human cell lines and shows their conservation in budding yeast.