Z. Wang

This study shows that lymphatic-preserving treatment sequences enhance cDC1-dependent antitumor immunity in HNSCC by avoiding lymphablation, which compromises ICI response.

This study examines blood chemistry changes in goats during a 100-year rain event linked to coccidiosis, suggesting potential clinical applications and climate change implications.

The paper identifies tuftsin as a natural human molecule that targets ACE2 and NRP1, impairing SARS-CoV-2 infection and suggesting its potential as a therapeutic for COVID-19.

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

Skopi generates diffraction images for various XFEL experiments to aid in developing feedback mechanisms for non-crystalline biomolecular structure analysis.

The paper uses computational methods to study fluoride permeation through fluoride channels, finding that electronic polarization plays a key role in F- selectivity and transport.

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

The paper uses DC-iDEP to isolate insulin vesicles from pancreatic β-cells and identifies distinct distribution patterns in response to glucose stimulation.

This study investigates the inactivation effect of UVCLED on Acinetobacter baumannii, showing that high irradiance improves sterilization efficiency and causes distinct structural and genomic damage.

The paper uses cryo-ET to identify structural changes in platelets during pre-acute myeloid leukemia, suggesting these changes could serve as an early diagnostic biomarker.

The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

The paper presents the first structure of native nebulin bound to thin filaments in sarcomeres, revealing interactions with actin and myosin conformations, and the molecular basis of nebulin's role in muscle function.

The paper identifies proteasome-associated HECT-type ubiquitin ligases that relay and process hormone-specific transcriptional activators, regulating their activity and stability.

The paper uses imaging spectroscopy to link aboveground vegetation properties with belowground soil processes in two grassland experiments, finding contrasting relationships based on ecosystem productivity and diversity.

This study identifies {Delta}7-DA as the endogenous ligand for Ss-DAF-12 in Strongyloides stercoralis and shows its potential as a therapeutic target when combined with ivermectin.

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

This paper introduces a gRNA-free RNA editing system called REWIRE that achieves high editing efficiency and low off-target effects in human and mouse cells.

The paper describes a framework using targeted phage display to identify conserved epitopes on the SARS-CoV-2 Spike protein for universal vaccine development.

The paper identifies how EPS1, a BAHD acyltransferase, evolved to catalyze a unique lyase reaction in SA biosynthesis in Brassicaceae plants through active site reconfiguration.

This study uses scRNA-seq to analyze lung cellular heterogeneity and host response during severe influenza infection in mice, identifying key immune and non-immune cell changes and communication dynamics.

This study investigates how calreticulin exon-9 INDEL mutations affect calcium signaling and contribute to essential thrombocythemia through structural changes and reduced calcium binding.

This study examines memory B cell evolution 5 months after mRNA vaccination in naive individuals, finding increased neutralizing activity but no further breadth or potency, and higher overall plasma neutralizing potency compared to natural infection.

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

This study evaluates the neutralizing capacity and protective efficacy of human polyclonal IgG against SARS-CoV-2 variants in vitro and in a transgenic hamster model.

This study examines age-related cellular changes in the rotator cuff enthesis of rats, finding increased mineralization and reduced tenogenic and chondrogenic potential in aged cells.

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.